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首页> 外文期刊>Journal of women’s health >Sex and Gender Analysis of Toxicity and Epidemiology Data on Environmental Chemicals in the Three Major Toxicology Databases
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Sex and Gender Analysis of Toxicity and Epidemiology Data on Environmental Chemicals in the Three Major Toxicology Databases

机译：三大毒理学数据库环境化学品毒性与流行病学数据的性和性别分析

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摘要

Background: As sex and gender are important considerations in the assessment of toxic chemicals, we investigated whether sex and gender issues have been adequately considered in toxicological databases. Materials and Methods: A systemic review was conducted on the toxicity and epidemiology data of eight environmental chemicals (i.e., cadmium [Cd], lead [Pb], benzene, toluene, formaldehyde, and tetrachloroethylene [TCE], bis(2-ethylhexyl) phthalate [DEHP], and bisphenol A [BPA]) that appear in three toxicological databases (i.e., Hazardous Substances Data Bank, Integrated Risk Information System, and the European Chemicals Agency databases). Results: Systemic reviews on 4160 data entries pertaining to eight chemicals in three databases revealed that only 13.5% of these were sourced from male and female combined (MF) studies, whereas, 40.6% of the total number of examined entries was sourced from the study in which the sex of the subject was not mentioned. Conclusions: To accurately evaluate the hazardous effect of chemicals, toxicity tests should be designed and conducted for both sexes, and the corresponding endpoints should cover gender concerns. Therefore, databases listing toxicity data as part of the open source literature should select information from MF toxicity and epidemiology studies.
机译：背景：由于性别和性别是有毒化学品评估中的重要考虑因素，我们调查了毒理学数据库中是否充分考虑了性别和性别问题。材料和方法：对8种环境化学物质（镉[Cd]、铅[Pb]、苯、甲苯、甲醛和四氯乙烯[TCE]、邻苯二甲酸二（2-乙基己基）酯[DEHP]的毒性和流行病学数据进行了系统综述，以及出现在三个毒理学数据库（即危险物质数据库、综合风险信息系统和欧洲化学品管理局数据库）中的双酚A[BPA]）。结果：对三个数据库中涉及八种化学品的4160个数据条目进行系统审查后发现，其中只有13.5%来自男性和女性联合（MF）研究，而检查条目总数的40.6%来自未提及受试者性别的研究。结论：为了准确评估化学品的有害影响，应为两性设计和进行毒性试验，相应的终点应涵盖性别问题。因此，作为开源文献的一部分列出毒性数据的数据库应该从MF毒性和流行病学研究中选择信息。

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