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首页> 外文期刊>日本香粧品学会誌 >A Novel'Anti-Pollution Cosmetic Ingredient,Phellodendron amurense Bark Extract,Attenuates Air Pollution-Induced Oxidative Stress and Inflammatory Reactions of Human Keratinocytes(HaCaT) via the AhR-Nrf2 Pathway
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A Novel'Anti-Pollution Cosmetic Ingredient,Phellodendron amurense Bark Extract,Attenuates Air Pollution-Induced Oxidative Stress and Inflammatory Reactions of Human Keratinocytes(HaCaT) via the AhR-Nrf2 Pathway

机译：一种新颖的“抗污染化妆品成分，Phellodendron Amurense Bark提取物，通过AHR-NRF2途径衰减人角质形成细胞（HACAT）的空气污染诱导的氧化应激和炎症反应

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Recent epidemiological studies have demonstrated that air pollution is one of the risk factors for developing skin aging,which is characterized by pigmented spots such as solar lentigos,wrinkles and sagging.Therefore,daily skin care is an important treatment to alleviate the adverse effects of air pollutants on the skin.In this study,we investigated the effects of Phellodendron amurense Bark Extract(PABE) on oxidative stress and the secretion of an inflammatory cytokine by HaCaT keratinocytes treated with diesel exhaust particles(DEP),SRM1975,a model of air pollutants.In general,air pollutants induce a detoxifying enzyme,CYPIAI,and increase oxidative stress through the activation of aryl hydrocarbon receptor(AhR).Treatment with PABE significantly suppressed levels of reactive oxygen species(ROS) and the secretion of IL-8 by HaCaT keratinocytes treated with DEP without affecting the mRNA expression level of CYPIAL Furthermore,treatment with PABE significantly suppressed the matrix metalloproteinase-1(MMP-1) activity of normal human dermal fibroblasts(NHDFs) cultured with the conditioned medium of DEP-treated HaCaT keratinocytes.Treatment with PABE increased the mRNA expression levels of y-GCS and NQOl due to increased levels of Nrf2.Based on these results,we conclude that PABE alleviates the progression of skin aging due to the removal of oxidative stress without affecting the metabolism of polycyclic aromatic hydrocarbons(PAHs).In conclusion,PABE is expected to be an effective cosmetic ingredient that prevents the acceleration of skin aging by air pollutants.
机译：最近的流行病学研究表明，空气污染是发展皮肤衰老的一个危险因素，它是由松散的点（如Solar Lentigos、Wrinkles和Sagging）引起的。因此，每日皮肤护理是一种重要的治疗方法，以提高空气污染物对皮肤的影响。In this study，we investigated the effects of phellodendron amurense bark extract（PABE）on oxidative stress and the section of an inflammatory cytokine by Hacat Keratinocytes treated with diesel exhaust particles（DEP），SRM1975，a model of air pollutants.In general，air pollutants induce a detoxifying enzyme，cypiai，and increase oxidative stress through the activation of aryl hydrocarbon receptor（AHR）.Treatment with pabe significantly suppressed levels of reactive oxygen species（ROS）and the secretion of IL-8 by hacat keratinocytes treated with Dep without affecting the mrna expression level of cypial furthermore，Treatment with pabe significantly suppressed the matrix metallproteinase-1（MMP-1）activity of normal human dermal fibroblasts（NHDFS）cultureurecultural d with the conditioned medium of dep-treated hacat keratinocytes.Treatment with Pabe increased the MRNA expression levels of Y-GCS and NQOL due to increased levels of NRF2.根据这些结果，我们得出结论，PABE将皮肤加速衰老的进展归因于去除氧化压力，而不影响多环芳烃（PAHS）的形而上学。在结论中，PABE希望成为一个有效的宇宙注入，防止皮肤被空气污染加速。

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