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首页> 外文期刊>Brain research >Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat
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Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat

机译：大鼠Ponto-medullary呼吸网的Periaquental灰色的互惠连接性

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Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory motor activities in the context of behavior and emotion via descending projections to nucleus retroambiguus. However, alternative anatomical pathways for the mediation of PAG-evoked respiratory modulation via core nuclei of the brainstem respiratory network remains only partially described. We injected the retrograde tracer Cholera toxin subunit B (CT-B) in the pontine Kolliker-Fuse nucleus (KFn, n = 5), medullary Botzinger (BbtC, n = 3) and pre-Botzinger complexes (pre-BotC; n = 3), and the caudal raphe nuclei (n = 3), and quantified the descending connectivity of the PAG targeting these brainstem respiratory regions. CT-B injections in the KFn, pre-BotC, and caudal raphe, but not in the BotC, resulted in CT-B-labeled neurons that were predominantly located in the lateral and ventrolateral PAG columns. In turn, CT-B injections in the lateral and ventrolateral PAG columns (n = 4) produced the highest numbers of CT-B-labeled neurons in the KFn and far fewer numbers of labeled neurons in the pre-BotC, BotC, and caudal raphe. Analysis of the relative projection strength revealed that the KFn shares the densest reciprocal connectivity with the PAG (ventrolateral and lateral columns, in particular). Overall, our data imply that the PAG may engage a distributed respiratory rhythm and pattern generating network beyond the nucleus retroambiguus to mediate downstream modulation of breathing. However, the reciprocal connectivity of the KFn and PAG suggests specific roles for synaptic interaction between these two nuclei that are most likely related to the regulation of upper airway patency during vocalization or other volitional orofacial behaviors.
机译：中脑导水管周围灰质（PAG）的突触活动可以通过下行投射到疑核后，调节或调节行为和情绪背景下的呼吸运动活动。然而，通过脑干呼吸网络的核心核介导PAG诱发的呼吸调节的替代解剖路径仍仅部分描述。我们在脑桥Kolliker融合核（KFn，n=5）、延髓Botzinger融合核（BbtC，n=3）和前Botzinger复合物（前BotC；n=3）以及中缝尾侧核（n=3）中注射逆行示踪剂霍乱毒素B亚单位（CT-B），并量化针对这些脑干呼吸区域的PAG的下行连通性。在KFn、BotC前区和中缝尾侧注射CT-B，但在BotC中不注射，导致CT-B标记的神经元主要位于外侧和腹外侧PAG柱。反过来，在外侧和腹外侧PAG柱（n=4）注射CT-B在KFn中产生最多的CT-B标记神经元，而在BotC前、BotC和中缝尾侧产生更少的标记神经元。对相对投影强度的分析表明，KFn与PAG（尤其是腹外侧柱和外侧柱）具有最密集的相互连接。总的来说，我们的数据表明PAG可能在疑核后参与分布式呼吸节律和模式生成网络，从而介导下游的呼吸调节。然而，KFn和PAG的相互连接表明，这两个核之间的突触相互作用具有特定的作用，这很可能与发声或其他意志性口面部行为期间上呼吸道通畅的调节有关。

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