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首页> 外文期刊>Brain research >Estimates of brain age for gray matter and white matter in younger and older adults: Insights into human intelligence
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Estimates of brain age for gray matter and white matter in younger and older adults: Insights into human intelligence

机译：年轻人和老年人的灰质和白质脑年龄估计：对人类智慧的见解

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摘要

Aging entails a multifaceted complex of changes in macro- and micro-structural properties of human brain gray matter (GM) and white matter (WM) tissues, as well as in intellectual abilities. To better capture tissue-specific brain aging, we combined volume and distribution properties of diffusivity indices to derive subject-specific age scores for each tissue. We compared age-related variance between younger and older adults for GM and WM age scores, and tested whether tissue-specific age scores could explain different effects of aging on fluid (Gf) and crystalized (Gc) intelligence in younger and older adults. Chronological age was strongly associated with GM (R2 = 0.73) and WM (R2 = 0.57) age scores. The GM age score accounted for significantly more variance in chronological age in younger relative to older adults (p < 0.001), whereas the WM age score accounted for significantly more variance in chronological age in older compared to younger adults (p < 0.025). Consistent with existing literature, younger adults outperformed older adults in Gf while older adults outperformed younger adults in Gc. The GM age score was negatively associated with Gf in younger adults (p < 0.02), whereas the WM age score was negatively associated with Gc in older adults (p < 0.02). Our results provide evidence for differences in the effects of age on GM and WM in younger versus older adults that may contribute to age-related differences in Gf and Gc.
机译：衰老涉及人脑灰质（GM）和白质（WM）组织的宏观和微观结构特性以及智力的多方面复杂变化。为了更好地捕捉组织特异性脑老化，我们结合扩散指数的体积和分布特性，得出每个组织的受试者特异性年龄分数。我们比较了年轻人和老年人的GM和WM年龄分数的年龄相关差异，并测试了组织特异性年龄分数是否可以解释年轻人和老年人的体液（Gf）和结晶（Gc）智力的不同老化效应。按时间顺序排列的年龄与GM（R2=0.73）和WM（R2=0.57）年龄评分密切相关。相对于老年人，GM年龄评分在年轻人中占比显著更大（p<0.001），而WM年龄评分在老年人中占比显著更大（p<0.025）。与现有文献一致，年轻人在Gf中的表现优于老年人，而老年人在Gc中的表现优于年轻人。年轻人的GM年龄评分与Gf呈负相关（p<0.02），而老年人的WM年龄评分与Gc呈负相关（p<0.02）。我们的结果为年轻人和老年人年龄对GM和WM的影响差异提供了证据，这可能导致Gf和Gc的年龄相关差异。

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