Spermatogonial stem-cell transplantation: an alternative approach for transgenesis in farm animals

Sharma Ankur; Kumaresan A.; Chauhan M. S.

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Spermatogonial stem-cell transplantation: an alternative approach for transgenesis in farm animals

机译：精牙科干细胞移植：农场动物转基因的另一种方法

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Genetic modification of spermatogonial stem cells followed by their transplantation to homologous recipients has shown immense potential to complement the current methods being used for generating transgenic farm animals. Using this technique, the time duration required to generate transgenic founder animals can be reduced at least by half, which would significantly reduce the generation interval. However, significant efforts need to be made to improve the efficiency of transgenic offspring production for its successful implementation in large-scale production of therapeutic proteins for human use.

机译：精原干细胞的基因改造，然后将其移植到同源受体，已经显示出巨大的潜力，可以补充目前用于生产转基因农场动物的方法。使用这种技术，产生转基因创始动物所需的时间可以减少至少一半，这将显著缩短产生间隔。然而，为了成功地大规模生产供人类使用的治疗性蛋白质，需要做出重大努力来提高转基因后代的生产效率。

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《Current Science: A Fortnightly Journal of Research》 |2021年第2期|共2页
作者
Sharma Ankur; Kumaresan A.; Chauhan M. S.;
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作者单位

ICAR Natl Dairy Res Inst Theriogenol Lab Vet Gynaecol &

Obstet Southern Reg Stn Bengaluru 560030 India;

ICAR Natl Dairy Res Inst Theriogenol Lab Vet Gynaecol &

Obstet Southern Reg Stn Bengaluru 560030 India;

ICAR Natl Dairy Res Inst Karnal 132001 India;

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正文语种 eng
中图分类自然科学现状及发展;
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机译：犬精原干细胞的分离，遗传操作和移植：通过雄性种系向转基因进展
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机译：在小鼠中建立长循环精原干细胞群的年龄

Spermatogonial stem-cell transplantation: an alternative approach for transgenesis in farm animals

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