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首页> 外文期刊>American Journal of Physiology >IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus
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IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus

机译：IGF-1输注胎儿绵羊会增加器官生长，但不是刺激养分转移到胎儿

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摘要

Insulin-like growth factor-1 (IGF-1) is an important fetal growth factor. However, the role of fetal IGF-1 in increasing placental blood flow, nutrient transfer, and nutrient availability to support fetal growth and protein accretion is not well understood. Catheterized fetuses from late gestation pregnant sheep received an intravenous infusion of LR3 IGF-1 (LR3 IGF-1; n = 8) or saline (SAL; n - 8) for 1 wk. Sheep then underwent a metabolic study to measure uterine and umbilical blood flow, nutrient uptake rates, and fetal protein kinetic rates. By the end of the infusion, fetal weights were not statistically different between groups (SAL: 3.260 ±0.211 kg, LR3 IGF-1: 3.682 + 0.183; P = 0.15). Fetal heart, adrenal gland, and spleen weights were higher (P < 0.05), and insulin was lower in LR3 IGF-1 (P < 0.05). Uterine and umbilical blood flow and umbilical uptake rates of glucose, lactate, and oxygen were similar between groups. Umbilical amino acid uptake rates were lower in LR3 IGF-1 (P < 0.05) as were fetal concentrations of multiple amino acids. Fetal protein kinetic rates were similar. LR3 IGF-1 skeletal muscle had higher myoblast proliferation (P < 0.05). In summary, LR3 IGF-1 infusion for 1 wk into late gestation fetal sheep increased the weight of some fetal organs. However, because umbilical amino acid uptake rates and fetal plasma amino acid concentrations were lower in the LR3 IGF-1 group, we speculate that animals treated with LR3 IGF-1 can efficiently utilize available nutrients to support organ-specific growth in the fetus rather than by stimulating placental blood flow or nutrient transfer to the fetus. NEW & NOTEWORTHY After a 1-wk infusion of LR3 IGF-1, late gestation fetal sheep had lower umbilical uptake rates of amino acids, lower fetal arterial amino acid and insulin concentrations, and lower fetal oxygen content; however, LR-3 IGF-1-treated fetuses were still able to effectively utilize the available nutrients and oxygen to support organ growth and myoblast proliferation.
机译：胰岛素样生长因子-1（IGF-1）是一种重要的胎儿生长因子。然而，胎儿IGF-1在增加胎盘血流量、营养素转移和营养素可用性以支持胎儿生长和蛋白质植入方面的作用尚不清楚。晚期妊娠绵羊的导管插入术胎儿接受LR3 IGF-1（LR3 IGF-1；n=8）或生理盐水（SAL；n-8）静脉输注1周。然后，对绵羊进行代谢研究，以测量子宫和脐带血流量、养分吸收率和胎儿蛋白质动力学率。输注结束时，各组之间的胎儿体重没有统计学差异（SAL:3.260±0.211 kg，LR3 IGF-1:3.682+0.183；P=0.15）。胎儿心脏、肾上腺和脾脏重量较高（P<0.05），而LR3 IGF-1中的胰岛素较低（P<0.05）。两组之间的子宫和脐带血流量以及脐带葡萄糖、乳酸和氧气的摄取率相似。LR3 IGF-1的脐带氨基酸摄取率较低（P<0.05），胎儿的多种氨基酸浓度也较低。胎儿蛋白质动力学率相似。LR3-IGF-1骨骼肌成肌细胞增殖率较高（P<0.05）。总之，向妊娠晚期胎羊输注LR3 IGF-1 1 1周会增加某些胎儿器官的重量。然而，由于LR3 IGF-1组的脐带氨基酸摄取率和胎儿血浆氨基酸浓度较低，我们推测，使用LR3 IGF-1治疗的动物可以有效地利用可用的营养物质来支持胎儿的器官特异性生长，而不是刺激胎盘血流或营养物质转移到胎儿。新的和值得注意的是，在注射LR3 IGF-1 1 1周后，妊娠晚期胎羊的脐带氨基酸摄取率较低，胎儿动脉氨基酸和胰岛素浓度较低，胎儿氧含量较低；然而，LR-3 IGF-1处理的胎儿仍然能够有效地利用可用的营养和氧气来支持器官生长和成肌细胞增殖。

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