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首页> 外文期刊>American Journal of Physiology >Plasma brain-derived neurotrophic factor and dynamic cerebral autoregulation in acute response to glycemic control following breakfast in young men
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Plasma brain-derived neurotrophic factor and dynamic cerebral autoregulation in acute response to glycemic control following breakfast in young men

机译：在年轻男性早餐后，血浆脑源性神经营养因子和动态脑自动调节对血糖控制后的血糖控制

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摘要

We examined the acute impact of both low- and high-glycemic index (Gl) breakfasts on plasma brain-derived neurotrophic factor (BDNF) and dynamic cerebral autoregulation (dCA) compared with breakfast omission. Ten healthy men (age 24 + 1 yr) performed three trials in a randomized crossover order; omission and Low-GI (GI = 40) and High-GI (Gl = 71) breakfast conditions. Middle cerebral artery velocity (transcranial Doppler ultrasonography) and arterial pressure (finger photoplethysmography) were continuously measured for 5 min before and 120 min following breakfast consumption to determine dCA using transfer function analysis. After these measurements of dCA, venous blood samples for the assessment of plasma BDNF were obtained. Moreover, blood glucose was measured before breakfast and every 30 min thereafter. The area under the curve of 2 h postprandial blood glucose in the High-GI trial was higher than the Low-GI trial (P < 0.01). The Gl of the breakfast did not affect BDNF. In addition, both very-low (VLF) and low-frequency (LF) transfer function phase or gains were not changed during the omission trial. In contrast, LF gain (High-GI P < 0.05) and normalized gain (Low-GI P < 0.05) were decreased by both Gl trials, while a decrease in VLF phase was observed in only the High-GI trial (P < 0.05). These findings indicate that breakfast consumption augmented dCA in the LF range but High-GI breakfast attenuated cerebral blood flow regulation against slow change (i.e., the VLF range) in arterial pressure. Thus we propose that breakfast and glycemic control may be an important strategy to optimize cerebrovascular health.
机译：我们研究了低血糖指数（Gl）和高糖指数（Gl）早餐与不吃早餐相比对血浆脑源性神经营养因子（BDNF）和动态脑自动调节（dCA）的急性影响。10名健康男性（年龄24+1岁）以随机交叉顺序进行了三项试验；忽略和低GI（GI=40）和高GI（Gl=71）早餐条件。在早餐前5分钟和早餐后120分钟，连续测量大脑中动脉速度（经颅多普勒超声）和动脉压（手指光体积描记术），使用传递函数分析确定dCA。在这些dCA测量之后，获得用于评估血浆BDNF的静脉血样本。此外，早餐前和早餐后每30分钟测量一次血糖。高GI试验餐后2h血糖曲线下面积高于低GI试验（P<0.01）。早餐的Gl对BDNF没有影响。此外，在遗漏试验期间，极低（VLF）和低频（LF）传递函数相位或增益均未发生变化。相比之下，两个Gl试验的LF增益（高GI P<0.05）和标准化增益（低GI P<0.05）均降低，而只有高GI试验的VLF期降低（P<0.05）。这些发现表明，早餐摄入增加了LF范围内的dCA，但高GI早餐减弱了动脉压缓慢变化（即VLF范围）下的脑血流调节。因此，我们认为早餐和血糖控制可能是优化脑血管健康的重要策略。

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