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Nanobiodevices for Biomolecule Analysis and Imaging

机译:用于生物分子分析和成像的纳米生物设备

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摘要

Nanobiodevices have been developed to analyze biomolecules and cells for biomedical applications. In this review, we discuss several nanobiodevices used for disease-diagnostic devices, molecular imaging devices, regenerative medicine, and drug-delivery systems and describe the numerous advantages of nanobiodevices, especially in biological, medical, and clinical applications. This review also outlines the fabrication technologies for nanostructures and nanomaterials, including top-down nanofabrication and bottom-up molecular self-assembly approaches. We describe nanopillar arrays and nanowall arrays for the ultrafast separation of DNA or protein molecules and nanoball materials for the fast separation of a wide range of DNA molecules, and we present examples of applications of functionalized carbon nanotubes to obtain information about subcellular localization on the basis of mobility differences between free fluorophores and fluorophore-labeled carbon nanotubes. Finally, we discuss applications of newly synthesized quantum dots to the screening of small interfering RNA, highly sensitive detection of disease-related proteins, and development of cancer therapeutics and diagnostics.
机译:已开发出纳米生物装置来分析生物分子和细胞以用于生物医学应用。在这篇综述中,我们讨论了用于疾病诊断设备,分子成像设备,再生医学和药物递送系统的几种纳米生物设备,并描述了纳米生物设备的众多优势,尤其是在生物,医学和临床应用中。本文还概述了纳米结构和纳米材料的制造技术,包括自上而下的纳米制造和自下而上的分子自组装方法。我们描述了用于超快分离DNA或蛋白质分子的纳米柱阵列和纳米壁阵列,以及用于快速分离各种DNA分子的纳米球材料,并在此基础上介绍了功能化碳纳米管的应用实例,以获取有关亚细胞定位的信息荧光团和荧光团标记的碳纳米管之间的迁移率差异最后,我们讨论了新合成的量子点在小干扰RNA的筛选,疾病相关蛋白的高灵敏度检测以及癌症治疗和诊断方法开发中的应用。

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