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首页> 外文期刊>Annual Review of Analytical Chemistry >Electrochemical Analysis of Neurotransmitters
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Electrochemical Analysis of Neurotransmitters

机译：神经递质的电化学分析

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摘要

Chemical signaling through the release of neurotransmitters into the extracellular space is the primary means of communication between neurons. More than four decades ago, Ralph Adams and his colleagues realized the utility of electrochemical methods for the study of easily oxidizable neurotransmitters, such as dopamine, norepinephrine, and serotonin and their metabolites. Today, electrochemical techniques are frequently coupled to microelectrodes to enable spatially resolved recordings of rapid neurotransmitter dynamics in a variety of biological preparations spanning from single cells to the intact brain of behaving animals. In this review, we provide a basic overview of the principles underlying constant-potential amperometry and fast-scan cyclic voltammetry, the most commonly employed electrochemical techniques, and the general application of these methods to the study of neurotransmission. We thereafter discuss several recent developments in sensor design and experimental methodology that are challenging the current limitations defining the application of electrochemical methods to neurotransmitter measurements.
机译：通过神经递质释放到细胞外空间的化学信号传递是神经元之间交流的主要手段。四十多年前，拉尔夫·亚当斯（Ralph Adams）和他的同事意识到电化学方法在研究易于氧化的神经递质（如多巴胺，去甲肾上腺素和血清素及其代谢物）中的实用性。如今，电化学技术经常与微电极耦合，以实现从单个细胞到行为动物完整大脑的多种生物制剂中空间分辨的快速神经递质动态记录。在这篇综述中，我们提供了恒电位安培法和快速扫描循环伏安法的基本原理，最常用的电化学技术以及这些方法在神经传递研究中的一般应用。此后，我们将讨论传感器设计和实验方法的一些最新进展，这些正在挑战当前的局限性，这些局限性定义了电化学方法在神经递质测量中的应用。

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