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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Long-term exposure to ambient PM1 strengthened the association of depression/anxiety symptoms with poor sleep quality: The Henan Rural Cohort study
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Long-term exposure to ambient PM1 strengthened the association of depression/anxiety symptoms with poor sleep quality: The Henan Rural Cohort study

机译：长期暴露于环境PM1加强抑郁/焦虑症状与睡眠质量差的关联：河南农村队列研究

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摘要

Evidence from numerous epidemiological studies for the relationship between mental disorder and sleep quality was inconclusive and few studies assessed the modification effect of exposure to ambient air PM1 (particulate matter with an aerodynamic diameter = 6 was classified as poor sleep quality. The three-year average exposure concentration of PM1 before the baseline survey was determined as long-term exposure concentration of ambient PM1. Logistic regression model was conducted to estimate the independent or joint effect of depression/anxiety symptoms and ambient PM1 exposure on poor sleep quality. In the adjusted models, the odds ratios (ORs) and 95% confidence intervals (95% CIs) of poor sleep quality associated with depression and anxiety symptoms were 3.75 (3.37, 4.17) and 3.42 (3.06, 3.81), respectively, and that associated with long-term exposure to PM1 was 1.06 (1.03, 1.09). An interaction effect was observed between anxiety symptoms score and PM1 concentration on poor sleep quality. With the increment of PM1 concentration, the association was strengthened between depression/anxiety symptoms and poor sleep quality. Besides, compared with the reference group, the ORs (95% CIs) of poor sleep quality in those with comorbidity of depression and anxiety symptoms were 4.98 (3.95, 6.29), 5.23 (3.98, 6.87), 5.76 (4.42, 7.49), and 5.58 (3.83, 8.14), respectively, from the first to the fourth quartile level of the PM1 concentration. These findings suggested that long-term exposure to PM1 strengthened the association of depression/anxiety symptoms with poor sleep quality in rural China.
机译：关于精神障碍和睡眠质量之间关系的许多流行病学研究的证据都没有定论，很少有研究评估暴露于环境空气PM1的改善效果（空气动力学直径=6的颗粒物被归类为睡眠质量差。基线调查前三年PM1的平均暴露浓度被确定为环境PM1的长期暴露浓度。采用逻辑回归模型来估计抑郁/焦虑症状和环境PM1暴露对睡眠质量差的独立或联合影响在调整后的模型中，与抑郁和焦虑症状相关的睡眠质量差的优势比（OR）和95%置信区间（95%CI）分别为3.75（3.37,4.17）和3.42（3.06,3.81），与长期暴露于PM1相关的优势比（OR）和95%置信区间（95%CI）分别为1.06（1.03,1.09）。焦虑症状评分与PM1浓度对睡眠质量的影响存在交互作用。随着PM1浓度的增加，抑郁/焦虑症状与睡眠质量差之间的关联增强。此外，与对照组相比，从PM1浓度的第一至第四个四分位水平来看，抑郁和焦虑症状共病患者睡眠质量差的ORs（95%CI）分别为4.98（3.95,6.29）、5.23（3.98,6.87）、5.76（4.42,7.49）和5.58（3.83,8.14）。这些发现表明，在中国农村，长期暴露于PM1加强了抑郁/焦虑症状与睡眠质量差的关联。

著录项

  • 来源
  • 作者

    He Yaling; Liu Xiaotian; Luo Zhicheng; Wang Yan; Fan Keliang; Tu Runqi; Wu Xueyan; Chen Gongbo; Hou Jian; Mao Zhenxing; Huo Wenqian; Li Shanshan; Guo Yuming; Wang Chongjian;

  • 作者单位

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Sun Yat Sen Univ Sch Publ Hlth Dept Occupat &

    Environm Hlth Guangdong Prov Engn Technol Res Ctr;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Monash Univ Sch Publ Hlth &

    Prevent Med Dept Epidmiol &

    Prevent Med Melbourne Vic Australia;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

    Zhengzhou Univ Dept Epidemiol &

    Biostat Coll Publ Hlth 100 Kexue Ave Zhengzhou 450001 Henan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Depression symptoms; Anxiety symptoms; PM1; Poor sleep quality; Joint effects;

    机译：抑郁症状;焦虑症状;PM1;睡眠质量差;联合效应;

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