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首页> 外文期刊>European Journal of Medicinal Chemistry: Chimie Therapeutique >Emerging trends of receptor-mediated tumor targeting peptides: A review with perspective from molecular imaging modalities
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Emerging trends of receptor-mediated tumor targeting peptides: A review with perspective from molecular imaging modalities

机译：受体介导的肿瘤靶向肽的新出现趋势：分子成像模态的观点综述

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Natural peptides extracted from natural components such are known to have a relatively short in-vivo half-life and can readily metabolize by endo- and exo-peptidases. Fortunately, synthetic peptides can be easily manipulated to increase in-vivo stability, membrane permeability and target specificity with some well-known natural families. Many natural as well as synthetic peptides target to their endogenous receptors for diagnosis and therapeutic applications. In order to detect these peptides externally, they must be modified with radionuclides compatible with single photon emission computed tomography (SPECT) or positron emission tomography (PET). Although, these techniques mainly rely on physiological changes and have profound diagnostic strength over anatomical modalities such as MRI and CT. However, both SPECT and PET observed to possess lack of anatomical reference frame which is a key weakness of these techniques, and unfortunately, cannot be available freely in most clinical centres especially in under-developing countries. Hence, it is need of the time to design and develop economic, patient friendly and versatile strategies to grapple with existing problems without any hazardous side effects. Optical molecular imaging (OMI) has emerged as a novel technique in field of medical science using fluorescent probes as imaging modality and has ability to couple with organic drugs, small molecules, chemotherapeutics, DNA, RNA, anticancer peptide and protein without adding chelators as necessary for radionuclides. Furthermore, this review focuses on difference in imaging modalities and provides ample knowledge about reliable, economic and patient friendly optical imaging technique rather radionuclide-based imaging techniques. (C) 2021 Elsevier Masson SAS. All rights reserved.
机译：从天然组分中提取的天然肽，如已知的在体半衰期相对较短，并且可以很容易地通过内肽酶和外肽酶进行代谢。幸运的是，合成肽可以很容易地进行操作，以增加体内稳定性、膜通透性和一些已知的天然家族的靶向特异性。许多天然和合成肽以其内源性受体为靶点，用于诊断和治疗应用。为了从外部检测这些肽，必须使用与单光子发射计算机断层扫描（SPECT）或正电子发射断层扫描（PET）兼容的放射性核素对其进行修饰。尽管如此，这些技术主要依赖于生理变化，与MRI和CT等解剖模式相比，具有深远的诊断优势。然而，SPECT和PET都缺乏解剖学参考框架，这是这些技术的一个关键弱点，不幸的是，在大多数临床中心，尤其是在发展中国家，无法免费获得。所以，需要时间来设计和开发经济的、对患者友好的和多功能的策略，以在不产生任何有害副作用的情况下解决现有问题。光学分子成像（OMI）是以荧光探针为成像手段，在医学领域发展起来的一项新技术，它能够与有机药物、小分子、化疗药物、DNA、RNA、抗癌肽和蛋白质进行偶联，而无需添加放射性核素所需的螯合剂。此外，本综述侧重于成像方式的差异，并提供了关于可靠、经济和患者友好的光学成像技术，而不是基于放射性核素的成像技术的充分知识。（c）2021爱思唯尔马松SAS。版权所有。

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