• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Rational design of hollow mesoporous titania nanoparticles loaded with curcumin for UV-controlled release and targeted drug delivery
【24h】

Rational design of hollow mesoporous titania nanoparticles loaded with curcumin for UV-controlled release and targeted drug delivery

机译：含有UV控制释放姜黄素的中空介孔二氧化钛纳米粒子的理性设计，靶向药物递送

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Curcumin (Cur), appeared to provide huge potential in biomedical application. However, its therapeutic efficacy was greatly limited as the result of poor solubility and instability. To address these limitations, we create a new type of hollow mesoporous titania nanoparticle (HMTN) to encapsulate Cur. HMTN was decorated with a layer of hydrophilic polyethylenimine (PEI), which controlled the release rate of Cur inside the pore due to its dendritic structure. Combined with the folic acid (FA) mediated targeting effect, the potential multifunctional Cur loaded titania nanoparticle (Cur-FA-PEI-HMTN) showed excellent biocompatibility and bioavailability, as well as the UV-responsive drug release properties. The operating parameters to prepare hollow structure were studied and the Cur-FA-PEI-HMTN nanosystem had been fully characterized by Brunauer-Emmet-Teller, Fourier transform infrared spectroscopy, transmission electron microscope, thermal gravity analysis, differential thermal analysis, x-ray diffraction, dynamic light scattering and zeta potential. In addition, the hemolytic test, as well as CCK8, flow cytometry, Hoechst 33342 staining experiment, were carried out to confirm the low cytotoxity and high biocompatibility. The confocal microscopy analysis results also revealed the increasing uptake of Cur@FA-PEI-HMTN by MCF-7 cells. The synthesized nanoparticles displayed great potential as drug nanovehicles with high biocompatibility.
机译：姜黄素（Cur）在生物医学领域具有巨大的应用潜力。然而，由于溶解度和不稳定性差，其治疗效果受到很大限制。为了解决这些局限性，我们创造了一种新型中空介孔二氧化钛纳米颗粒（HMTN）来封装Cur。HMTN表面修饰了一层亲水性聚乙烯亚胺（PEI），由于其树枝状结构，可以控制孔内Cur的释放速率。结合叶酸（FA）介导的靶向效应，潜在的多功能Cur负载二氧化钛纳米颗粒（Cur-FA-PEI-HMTN）显示出优异的生物相容性和生物利用度，以及UV响应性药物释放特性。研究了制备中空结构的操作参数，并通过Brunauer-Emmet-Teller、傅里叶变换红外光谱、透射电子显微镜、热重分析、差热分析、x射线衍射、动态光散射和zeta电位对Cur-FA-PEI HMTN纳米系统进行了全面表征。此外，还进行了溶血试验，以及CCK8、流式细胞术、Hoechst 33342染色实验，以确认其低细胞毒性和高生物相容性。共聚焦显微镜分析结果还显示，细胞的摄取量增加Cur@FA-通过MCF-7细胞获得PEI-HMTN。合成的纳米颗粒具有良好的生物相容性，有望成为药物纳米载体。

著录项

  • 来源
    《Nanotechnology》 |2021年第20期|共15页
  • 作者

    Mai Zhuoxian; Chen Jiali; Cao Qingyun; Hu Yang; Dong Xianming; Zhang Hongwu; Huang Wenhua; Zhou Wuyi;

  • 作者单位

    South China Agr Univ Coll Mat &

    Energy Key Lab Biobased Mat &

    Energy Minist Educ Guangzhou Peoples R China;

    Southern Med Univ Dept Anat Guangdong Prov Key Lab Construct &

    Detect Tissue Guangzhou 510515 Peoples R China;

    South China Agr Univ Coll Anim Sci Guangzhou 510642 Peoples R China;

    South China Agr Univ Coll Mat &

    Energy Key Lab Biobased Mat &

    Energy Minist Educ Guangzhou Peoples R China;

    South China Agr Univ Coll Mat &

    Energy Key Lab Biobased Mat &

    Energy Minist Educ Guangzhou Peoples R China;

    Southern Med Univ Dept Anat Guangdong Prov Key Lab Construct &

    Detect Tissue Guangzhou 510515 Peoples R China;

    Southern Med Univ Dept Anat Guangdong Prov Key Lab Construct &

    Detect Tissue Guangzhou 510515 Peoples R China;

    South China Agr Univ Coll Mat &

    Energy Key Lab Biobased Mat &

    Energy Minist Educ Guangzhou Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    mesoporous titania nanoparticle; hollow; PEI; UV-responsive release; folic acid;

    机译：介孔二氧化钛纳米颗粒;空洞的裴;紫外线响应释放;叶酸;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号