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首页> 外文期刊>Nanotechnology >NaYF4:Yb/Tm@SiO2-Dox/Cur-CS/OSA nanoparticles with pH and photon responses
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NaYF4:Yb/Tm@SiO2-Dox/Cur-CS/OSA nanoparticles with pH and photon responses

机译：Nayf4：Yb / TM / TM / CIO2-DOX / CUR-CS / OSA纳米粒子，具有pH和光子响应

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摘要

Stimulus-triggered drug delivery systems (DDSs) based on lanthanide-doped upconversion nanoparticles (UCNPs) have attracted significant attention for treating cancers due to their merits of high drug availability, precisely controlled drug release, and low side-effects. However, such DDSs usually exhibit a single stimulus-response, which may limit the efficiency of cancer treatment. To extend response types in a single DDS, we construct NaYF4:Yb/Tm@SiO2-doxorubicin (Dox)/curcumin (Cur)-chitosan (CS)/2-Octen-1-ylsuccinic anhydride (OSA) nanoparticles with core-shell structures. Our method is based on the exploration of the synergistic effect of UCNPs and multiple drugs. In particular, the NaYF4:Yb/Tm is used to convert near-infrared light to visible light, activating Cur photosensitizers to produce singlet oxygen for photodynamic therapy, while CS/OSA responds to a low pH environment to release cancer drugs, including Dox and Cur for chemotherapy through breaking a free carboxyl group. The results show that the UCNPs with a 40 nm diameter, 23 nm thick mesoporous SiO2, and 19/1 mol% Yb3+/Tm(3+)concentrations could continuously release Dox and Cur at a pH value of 6.5 within 6 h after the excitation of a 980 nm-wavelength CW laser. Our study provides a promising approach for developing efficient DDSs for cancer treatment.
机译：基于稀土掺杂上转换纳米颗粒（UCNP）的刺激触发给药系统（DDS）因其药物利用率高、药物释放精确、副作用小等优点，在治疗癌症方面引起了广泛关注。然而，这种DDS通常表现出单一的刺激反应，这可能会限制癌症治疗的效率。为了在单个DDS中扩展响应类型，我们构造了NaYF4:Yb/Tm@SiO2-具有核壳结构的阿霉素（Dox）/姜黄素（Cur）-壳聚糖（CS）/2-辛烯-1-基琥珀酸酐（OSA）纳米颗粒。我们的方法基于对UCNP和多种药物协同作用的探索。特别是，NaYF4:Yb/Tm用于将近红外光转换为可见光，激活Cur光敏剂以产生用于光动力疗法的单线态氧，而CS/OSA则对低pH环境作出反应，通过打破游离羧基释放癌症药物，包括用于化疗的Dox和Cur。结果表明，直径为40nm、厚度为23nm的介孔SiO2和浓度为19/1mol%Yb3+/Tm（3+）的UCNP在980nm波长的连续激光激发后6h内可在pH值为6.5的条件下连续释放Dox和Cur。我们的研究为开发用于癌症治疗的高效DDS提供了一种有希望的方法。

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