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Targeted antitumor comparison study between dopamine self-polymerization and traditional synthesis for nanoparticle surface modification in drug delivery

机译：多巴胺自聚聚类与传统合成的靶向抗肿瘤比较研究药物递送中纳米粒子表面改性

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摘要

To improve the therapeutic efficacy of anticancer agents and extend their application, mussel-inspired chemical modifications have attracted considerable attention. Surface modification based on polydopamine (PDA) has been a facile and versatile method to immobilize biomolecules on substrates for targeted drug delivery. To better analyze pharmaceutical differences between PDA-based surface modification and traditional synthesis methods, we prepared two kinds of folate (FA)-targeted nanoparticles (NPs) loaded with paclitaxel (PTX). The resultant PTX-PDA-FA NPs and PTX-FA NPs represented PDA and synthesis strategies, respectively. PTX-PDA-FA NPs and PTX-FA NPs have been characterized. The particle size of PTX-PDA-FA NPs was smaller than that of PTX-FA NPs. The two kinds of NPs both exhibited long-rod morphology, good colloidal stability and sustained slow drug release. Cytotoxicity in vitro was evaluated, and antitumor efficacy was investigated against 4T1 tumor-bearing mice. The tumor targeting therapeutic index of PTX-PDA-FA NPs and PTX-FA NPs showed equivalent superior specificity compared to nontargeted groups, which indicated that FA successfully attached to the surface of NPs by the PDA method and that the antitumor effect was equivalent to that of FA-modified NPs prepared by the chemical synthesis method. These results further indicated that PDA, as a simple and effective chemical surface modification platform, could be developed and applied in targeted delivery systems.
机译：为了提高抗癌药物的治疗效果并扩大其应用范围，贻贝激发的化学修饰引起了广泛关注。基于聚多巴胺（PDA）的表面修饰是一种简便、通用的方法，可以将生物分子固定在基底上，用于靶向给药。为了更好地分析基于PDA的表面修饰和传统合成方法之间的药物差异，我们制备了两种负载紫杉醇（PTX）的叶酸（FA）靶向纳米颗粒（NPs）。合成的PTX-PDA-FA NP和PTX-FA NP分别代表PDA和合成策略。已经对PTX-PDA-FA NPs和PTX-FA NPs进行了表征。PTX-PDA-FA纳米颗粒的粒径小于PTX-FA纳米颗粒的粒径。这两种纳米粒均表现出长棒状形态、良好的胶体稳定性和持续的缓慢药物释放。对体外细胞毒性进行了评估，并对4T1荷瘤小鼠的抗肿瘤效果进行了研究。PTX-PDA-FA纳米粒和PTX-FA纳米粒的肿瘤靶向治疗指数与非靶向组相比显示出同等优越的特异性，这表明通过PDA方法FA成功地附着在纳米粒表面，并且其抗肿瘤作用与通过化学合成方法制备的FA修饰纳米粒相当。这些结果进一步表明，PDA作为一种简单有效的化学表面改性平台，可以开发并应用于靶向给药系统。

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  • 来源
    《Nanotechnology》 |2021年第30期|共11页
  • 作者

    Zhang Mengying; Zou Yuan; Zuo Cuiling; Ao Hui; Guo Yifei; Wang Xiangtao; Han Meihua;

  • 作者单位

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

    Chinese Acad Med Sci &

    Peking Union Med Coll Inst Med Plant Dev Beijing 100193 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    nanoparticles; folate-mediated targeting; chemical modification; polydopamine; antitumor;

    机译：纳米颗粒;叶酸介导靶向;化学改性;多多巴胺;抗肿瘤;

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