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首页> 外文期刊>Nanotechnology >Development of a multifunctional system based on CoFe2O4@polyacrylic acid NPs conjugated to folic acid and loaded with doxorubicin for cancer theranostics
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Development of a multifunctional system based on CoFe2O4@polyacrylic acid NPs conjugated to folic acid and loaded with doxorubicin for cancer theranostics

机译：基于CoFe2O4的多功能系统的开发与叶酸缀合的COFE2O4 @聚丙烯酸NPS，用癌症治疗癌症

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摘要

In this work, a multifunctional theranostic nanocomposite based on CoFe2O4@polyacrylic acid (PAA)-Folic Acid (FA) Doxorubicin (Dox)(load) NPs was designed for the multifunctional cancer treatment. Several techniques such as TEM, DLS, zeta-potential, vibrating sample magnetometer, XRD, and UV-Vis spectrophotometer were applied for investigating physicochemical properties of the nanosystem. The percentage of the loaded drug, loading efficiency, in vitro release (pH 5.4 and 7.4), in vitro MRI measurements, and MTT assay (4T1 and 9A9 cell lines) were evaluated. Results showed that the percentage of loaded drug and loading efficiency was 53.33 +/- 3.5 and 80.00 +/- 5.3%, respectively, showing the system's high ability for Dox encapsulation. Release study showed that Dox loaded in the CoFe2O4@PAA-FA(Dox)(load) NPs released faster at pH 5.4 than pH 7.4. In vitro, MRI measurements confirmed that CoFe2O4@PAA NPs could be used as a contrast agent in MRI measurements with r (2) = 18.2 mM(-1) s(-1). MTT assay demonstrated the biocompatibility of NPs, also showed a more efficient therapeutic effect for CoFe2O4@PAA-FA(Dox)(load) NPs than free Dox and CoFe2O4@PAA(Dox)(load) NPs.
机译：在这项工作中，一种基于CoFe2O4@polyacrylic酸性（PAA）-叶酸（FA）阿霉素（Dox）（load）NPs被设计用于多功能癌症治疗。采用TEM、DLS、zeta电位、振动样品磁强计、XRD和UV-Vis分光光度计等技术研究了纳米体系的物理化学性质。评估载药百分比、载药效率、体外释放（pH 5.4和7.4）、体外MRI测量和MTT试验（4T1和9A9细胞系）。结果表明，载药率和载药效率分别为53.33+/-3.5%和80.00+/-5.3%，表明该系统具有较高的Dox包封能力。释放研究表明，Dox在CoFe2O4@PAA-pH值为5.4时，FA（Dox）（负载）NPs的释放速度快于pH值为7.4时。在体外，核磁共振测量证实了这一点CoFe2O4@PAA在r（2）=18.2mm（-1）s（-1）的MRI测量中，NPs可用作对比剂。MTT法证明了纳米粒的生物相容性，也表明纳米粒具有更有效的治疗效果CoFe2O4@PAA-FA（Dox）（负载）NPs比自由Dox和CoFe2O4@PAA（Dox）（负载）NPs。

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