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Roadmap on nanomedicine

机译：在纳米医生的路线图

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摘要

Since the launch of the Alliance for Nanotechnology in Cancer by the National Cancer Institute in late 2004, several similar initiatives have been promoted all over the globe with the intention of advancing the diagnosis, treatment and prevention of cancer in the wake of nanoscience and nanotechnology. All this has encouraged scientists with diverse backgrounds to team up with one another, learn from each other, and generate new knowledge at the interface between engineering, physics, chemistry and biomedical sciences. Importantly, this new knowledge has been wisely channeled towards the development of novel diagnostic, imaging and therapeutic nanosystems, many of which are currently at different stages of clinical development. This roadmap collects eight brief articles elaborating on the interaction of nanomedicines with human biology; the biomedical and clinical applications of nanomedicines; and the importance of patient stratification in the development of future nanomedicines. The first article reports on the role of geometry and mechanical properties in nanomedicine rational design; the second articulates on the interaction of nanomedicines with cells of the immune system; and the third deals with exploiting endogenous molecules, such as albumin, to carry therapeutic agents. The second group of articles highlights the successful application of nanomedicines in the treatment of cancer with the optimal delivery of nucleic acids, diabetes with the sustained and controlled release of insulin, stroke by using thrombolytic particles, and atherosclerosis with the development of targeted nanoparticles. Finally, the last contribution comments on how nanomedicine and theranostics could play a pivotal role in the development of personalized medicines. As this roadmap cannot cover the massive extent of development of nanomedicine over the past 15 years, only a few major achievements are highlighted as the field progressively matures from the initial hype to the consolidation phase.
机译：自国家癌症研究所于2004年底发起癌症纳米技术联盟以来，全球各地都在推广几项类似的倡议，目的是随着纳米科学和纳米技术的发展，推进癌症的诊断、治疗和预防。所有这些都鼓励了具有不同背景的科学家相互合作，相互学习，并在工程、物理、化学和生物医学科学之间产生新的知识。重要的是，这一新知识已被明智地引导到新型诊断、成像和治疗纳米系统的开发中，其中许多目前处于不同的临床开发阶段。该路线图收集了八篇关于纳米药物与人类生物学相互作用的简要文章；纳米药物的生物医学和临床应用；以及患者分层在未来纳米药物发展中的重要性。第一篇文章报道了几何和机械性能在纳米医学合理设计中的作用；第二部分阐述了纳米药物与免疫系统细胞的相互作用；第三个是利用内源性分子，如白蛋白，携带治疗药物。第二组文章重点介绍了纳米药物在癌症治疗中的成功应用，包括核酸的最佳输送、胰岛素的持续和控制释放的糖尿病、使用溶栓颗粒治疗中风，以及靶向纳米颗粒开发的动脉粥样硬化。最后，最后一篇文章评论了纳米医学和治疗学如何在个性化药物的发展中发挥关键作用。由于该路线图无法涵盖过去15年纳米医学的大规模发展，随着该领域从最初的炒作阶段逐步成熟到巩固阶段，仅强调了几项重大成就。

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  • 来源
    《Nanotechnology》 |2021年第1期|共26页
  • 作者

    Decuzzi Paolo; Peer Dan; Di Mascolo Daniele; Palange Anna Lisa; Manghnani Purnima Naresh; Moghimi S. Moein; Farhangrazi Z. Shadi; Howard Kenneth A.; Rosenblum Daniel; Liang Tingxizi; Chen Zhaowei; Wang Zejun; Zhu Jun-Jie; Gu Zhen; Korin Netanel; Letourneur Didier; Chauvierre Cedric; van der Meel Roy; Kiessling Fabian; Lammers Twan;

  • 作者单位

    Fdn Ist Italiano Tecnol Lab Nanotechnol Precis Med Via Morego 30 I-16163 Genoa Italy;

    Tel Aviv Univ Shmunis Sch Biomed &

    Canc Res Lab Precis NanoMed IL-6997801 Tel Aviv Israel;

    Fdn Ist Italiano Tecnol Lab Nanotechnol Precis Med Via Morego 30 I-16163 Genoa Italy;

    Fdn Ist Italiano Tecnol Lab Nanotechnol Precis Med Via Morego 30 I-16163 Genoa Italy;

    Fdn Ist Italiano Tecnol Lab Nanotechnol Precis Med Via Morego 30 I-16163 Genoa Italy;

    Newcastle Univ Sch Pharm Newcastle Upon Tyne NE1 7RU Tyne &

    Wear England;

    SM Discovery Grp Inc Boulder CO USA;

    Aarhus Univ Interdisciplinary Nanosci Ctr Dept Mol Biol &

    Genet Aarhus Denmark;

    Tel Aviv Univ Shmunis Sch Biomed &

    Canc Res Lab Precis NanoMed IL-6997801 Tel Aviv Israel;

    Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

    Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

    Nanjing Univ Sch Chem &

    Chem Engn State Key Lab Analyt Chem Nanjing 210023 Peoples R China;

    Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

    Technion Israel Inst Technol IL-3200003 Haifa Israel;

    Univ Paris Univ Paris Sorbonne Paris Nord INSERM U1148 LVTS Hop X Bichat F-75018 Paris France;

    Univ Paris Univ Paris Sorbonne Paris Nord INSERM U1148 LVTS Hop X Bichat F-75018 Paris France;

    Eindhoven Univ Technol Dept Biomed Engn Lab Chem Biol Eindhoven Netherlands;

    Univ Twente Dept Targeted Therapeut Enschede Netherlands;

    Rhein Westfal TH Aachen Inst Expt Mol Imaging Aachen Germany;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    nanomedicine; cancer therapy; diabetes; atherosclerosis; thrombolysis;

    机译：纳米医学;癌症治疗;糖尿病动脉粥样硬化;溶栓;

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