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首页> 外文期刊>Nanotechnology >Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery
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Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery

机译：丝绸工业废物蛋白质：电纺丝丝蛋白纳米纤维的分离，纯化和制造作为浮动药物递送的可能纳米载体

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摘要

Amongst assorted regio-selective and targeted oral drug delivery strategies accepted for the gastro-retentive drug delivery system (GRDDS), the floating drug delivery system (FDDS) holds a major share as clinically accepted formulations. The major objective of the present investigation was to explore the silk industry waste protein, silk fibroin (SF) as a possible electrospun nanocarrier for the FDDS. In a nutshell, electrospinning (ES) is one of the flexible and astonishing strategies for the fabrication of porous electrospun nanofibers (NFs), which offers the potential to amend the floating profile, dissolution rate, solubility, and release patterns of the drug, etc as per compendial requirements. Looking at the prospects of floating SF-NFs preparation, we have isolated and lyophilized the SF from industrial waste cocoons and prepared drug-loaded SF single polymer nanofibers (SPN). Lafutidine (LF) being a good candidate for GRDDS selected as a model drug, which is an excellent proton pump inhibitor, mainly used in the treatment of gastric ulcers. Finally, the obtained LF loaded SF-NFs (LF-SF-NFs) were successfully analyzed for physicochemical characteristics, porosity, swelling index, antioxidant activity, mucoadhesion strength, floating properties, enzymatic degradation, and accelerated stability study, etc. Further, these LF-SF-NFs were evaluated for percent drug content, weight variation, in-vitro dissolution in 0.1 N hydrochloric acid (HCl, pH:1.2) and fasted state simulated gastric fluid (FSSGF), and accelerated stability study. It has shown significant floating time >18 h, about 99% +/- 0.58% floating buoyancy with sustained release up to 24 h. LF-SF-NFs showed good compatibility, entrapment efficiency, antioxidant activity, mucoadhesion strength, enzymatic degradation, and long term stability. Soon, the essential floating and drug release profiles can claim single polymer (SF) based electrospun protein NFs as a possible novel oral nanocarrier for FDDS.
机译：在胃滞留给药系统（GRDDS）接受的各种区域选择性和靶向性口服给药策略中，漂浮给药系统（FDDS）作为临床接受的剂型占据了主要份额。本研究的主要目的是探索丝绸工业废料蛋白质丝素蛋白（SF）作为FDD的电纺纳米载体的可能性。简而言之，静电纺丝（ES）是制造多孔静电纺纳米纤维（NFs）的灵活且令人惊讶的策略之一，它提供了根据药典要求修改药物的漂浮轮廓、溶解速率、溶解度和释放模式等的潜力。展望了悬浮SF-NFs制备的前景，我们从工业废茧中分离并冻干SF，制备了载药SF单聚合物纳米纤维（SPN）。拉弗替丁（LF）是GRDD的良好候选模型药物，是一种优良的质子泵抑制剂，主要用于治疗胃溃疡。最后，成功地分析了所获得的负载LF的SF-NFs（LF-SF-NFs）的理化特性、孔隙率、溶胀指数、抗氧化活性、粘液粘附强度、漂浮性能、酶降解和加速稳定性研究等。此外，还评估了这些LF-SF-NFs的药物含量百分比、重量变化，在0.1 N盐酸（HCl，pH:1.2）和禁食状态模拟胃液（FSSGF）中的体外溶出，以及加速稳定性研究。LF-SF-NFs具有良好的相容性、包封率、抗氧化活性、粘液粘附强度、酶降解和长期稳定性。很快，基本的漂浮和药物释放曲线可以证明基于单聚合物（SF）的电纺蛋白NFs可能是FDD的新型口服纳米载体。

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