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首页> 外文期刊>Nanotechnology >Hyaluronic acid functionalized biodegradable mesoporous silica nanocomposites for efficient photothermal and chemotherapy in breast cancer
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Hyaluronic acid functionalized biodegradable mesoporous silica nanocomposites for efficient photothermal and chemotherapy in breast cancer

机译：透明质酸官能化可生物降解的介孔二氧化硅纳米复合材料用于高效的乳腺癌和化疗的乳腺癌

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摘要

Chemotherapy is one of conventional treatment methods for breast cancer, but drug toxicity and side effects have severely limited its clinical applications. Photothermal therapy has emerged as a promising method that, upon combination with chemotherapy, can better treat breast cancer. In this context, a biodegradable mesoporous silica nanoparticle (bMSN NPs) system was developed for loading doxorubicin (DOX) and IR780, to be potentially applied in the treatment of breast cancer. IR780 is encapsulated in the pores of bMSN NPs by hydrophobic adsorption, while DOX is adsorbed on the surface of the bMSN NPs by hyaluronic acid electrostatically, to form the bMID NPs. Transmission electron microscopy, fluorescence spectrum and UV absorption spectrum are used to prove the successful encapsulation of IR780 and the loading of DOX. In vitro experiments have shown bMID NPs present an excellent therapeutic effect on breast cancer cells. In vivo fluorescence imaging results have indicated that bMID NPs can accumulate in tumor sites gradually and achieve in vivo long-term circulation and continuous drug release. Furthermore, bMID NPs have provided obvious antitumor effects in breast cancer mouse models, thus evolving as an efficient platform for breast cancer therapy.
机译：化疗是乳腺癌的常规治疗方法之一，但药物的毒副作用严重限制了其临床应用。光热疗法是一种很有前途的方法，与化疗相结合可以更好地治疗乳腺癌。在此背景下，开发了一种可生物降解的介孔二氧化硅纳米颗粒（bMSN-NPs）系统，用于装载阿霉素（DOX）和IR780，有望应用于乳腺癌的治疗。IR780通过疏水吸附被包裹在bMSN NP的孔中，而DOX通过透明质酸静电吸附在bMSN NP的表面，形成bMID NP。利用透射电镜、荧光光谱和紫外吸收光谱证明了IR780的成功包封和DOX的负载。体外实验表明，bMID NPs对乳腺癌细胞具有良好的治疗效果。体内荧光成像结果表明，bMID纳米粒可以在肿瘤部位逐渐积聚，实现体内长期循环和持续药物释放。此外，bMID NP在乳腺癌小鼠模型中具有明显的抗肿瘤作用，因此逐渐成为乳腺癌治疗的有效平台。

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  • 来源
    《Nanotechnology》 |2021年第16期|共15页
  • 作者

    Zhan Wenhua; Li Hanrui; Guo Yingying; Yang Lu; Pang Liaojun; Zhang Chaolin;

  • 作者单位

    Xi An Jiao Tong Univ Sch Life Sci &

    Technol Educ Minist Key Lab Biomed Informat Engn Xian 710049 Shaanxi Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Minist Educ Engn Res Ctr Mol &

    Neuro Imaging Xian 710126 Shaanxi Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Minist Educ Engn Res Ctr Mol &

    Neuro Imaging Xian 710126 Shaanxi Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Minist Educ Engn Res Ctr Mol &

    Neuro Imaging Xian 710126 Shaanxi Peoples R China;

    Xidian Univ Sch Life Sci &

    Technol Minist Educ Engn Res Ctr Mol &

    Neuro Imaging Xian 710126 Shaanxi Peoples R China;

    Ningxia Med Univ Gen Hosp Dept Radiat Oncol Yinchuan 750004 Ningxia Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    chemotherapy; photothermal therapy; doxorubicin; IR780; biodegradable mesoporous silica nanoparticles; breast cancer;

    机译：化疗光热疗法;阿霉素;IR780;生物可降解介孔二氧化硅纳米颗粒;乳腺癌;

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