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Stabilization of DNA by sodium and magnesium ions during the synthesis of DNA-bridged gold nanoparticles

机译：钠和镁离子在合成DNA桥金纳米粒子的稳定下稳定DNA

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Nanostructures synthesized using DNA-conjugated gold nanoparticles have a wide range of applications in the field of biosensorics. The stability of the DNA duplex plays a critical role as it determines the final geometry of these nanostructures. The main way to control DNA stability is to maintain a high ionic strength of the buffer solution; at the same time, high salt concentrations lead to an aggregation of nanoparticles. In this study, by means of the instrumentality of DNA-bridged seeds using tris(hydroxymethyl)aminomethane as a soft reducing agent the dumbbell-like gold nanoparticles up to 35 nm were synthesized with a high concentration of sodium ions of up to 100 mM and magnesium ions up to 1 mM. We also examined at the atomic level the details of the effect of the gold nanoparticle surface, as well as Na+ and Mg2+ ions, on the stability of nucleotide pairs located in close proximity to the grafting site.
机译：利用DNA共轭金纳米粒子合成的纳米结构在生物传感器领域有着广泛的应用。DNA双链的稳定性起着关键作用，因为它决定了这些纳米结构的最终几何形状。控制DNA稳定性的主要方法是保持缓冲溶液的高离子强度；同时，高盐浓度导致纳米颗粒聚集。在这项研究中，通过使用三（羟甲基）氨基甲烷作为软还原剂的DNA桥联种子工具，合成了高浓度钠离子高达100 mM，镁离子高达1 mM的哑铃状金纳米颗粒，最大粒径为35 nm。我们还从原子水平上研究了金纳米粒子表面以及Na+和Mg2+离子对靠近接枝位点的核苷酸对稳定性的影响。

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