A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy dagger

Chang Zhijian; Ye Jia-Hai; Qi Fen; Fang Hongbao; Lin Fuyan; Wang Shuai; Mu Cancan; Zhang Wenchao; He Weijiang

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A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy dagger

机译：用于成像引导组合化疗和光动力疗法匕首的聚乙二醇化光敏剂 - 核心pH响应聚合物纳米载体

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A novel chemo-photodynamic combined therapeutic self-assembly polymeric platform (MPEG-Hyd-Br-2-BODIPY) was constructed based on 2,6-diBr-BODIPY as the photosensitizer core and MPEG as the hydrophilic side chain through hydrazone bond linkage which can successfully encapsulate DOX and exhibited an accelerated release rate with decreasing pH value from 7.4 to 5.0 which results in considerable time/dose-dependent cytotoxicity. In addition, the photosensitizer moieties embedded in MPEG-Hyd-Br-2-BODIPY could generate singlet oxygen (O-1(2)) effectively under light irradiation, which was expected to realize the synchronization therapy of chemo- and photodynamic therapy (PDT).

机译：以2,6-diBr-BODIPY为光敏剂核心，以MPEG为亲水性侧链，通过腙键连接，构建了一种新型的化学-光动力联合治疗性自组装聚合物平台（MPEG-Hyd-Br-2-BODIPY），该平台能成功包封DOX，并在pH值从7.4降至5.0的情况下加速释放速率，从而产生可观的效果时间/剂量依赖性细胞毒性。此外，嵌入在MPEG-Hyd-Br-2-BODIPY中的光敏剂部分能够在光照下有效地生成单线态氧（O-1（2）），有望实现化学和光动力疗法（PDT）的同步治疗。

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《New Journal of Chemistry》 |2021年第14期|共6页
作者
Chang Zhijian; Ye Jia-Hai; Qi Fen; Fang Hongbao; Lin Fuyan; Wang Shuai; Mu Cancan; Zhang Wenchao; He Weijiang;
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Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ State Key Lab Coordinat Chem Sch Chem &

Chem Engn Nanjing 210093 Peoples R China;

Nanjing Univ State Key Lab Coordinat Chem Sch Chem &

Chem Engn Nanjing 210093 Peoples R China;

Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ Sci &

Technol Sch Chem Engn Nanjing 210094 Peoples R China;

Nanjing Univ State Key Lab Coordinat Chem Sch Chem &

Chem Engn Nanjing 210093 Peoples R China;

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正文语种 eng
中图分类化学;
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6. pH-Responsive Polymer-Stabilized ZIF-8 Nanocomposites for Fluorescence and Magnetic Resonance Dual-Modal Imaging-Guided Chemo-/Photodynamic Combinational Cancer Therapy [J] . Qin Ya-Ting, Peng Hui, He Xi-Wen, ACS applied materials & interfaces . 2019,第37期

机译：pH-响应聚合物稳定的ZIF-8纳米复合材料用于荧光和磁共振双型成像引导的化学/光动力组合癌症治疗
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机译：JO-1联合治疗与化疗在卵巢癌模型中的应用。

A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy dagger

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