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首页> 外文期刊>New Journal of Chemistry >Metal-organic framework derived metal oxide/reduced graphene oxide nanocomposite, a new tool for the determination of dipyridamole
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Metal-organic framework derived metal oxide/reduced graphene oxide nanocomposite, a new tool for the determination of dipyridamole

机译：金属有机框架衍生金属氧化物/缩小的石墨烯氧化物纳米复合材料，一种用于测定二吡哚的新工具

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摘要

Dipyridamole is a prescribed medication used to treat cardiovascular diseases, angina pectoris, and myocardial infarction, and in imaging tests for heart patients. Therefore, a high selectivity and sensitivity, low cost, and high-performance speed test is needed to monitor this compound. In this work, a sensitive, selective, and rapid electrochemical sensor is developed based on a glassy carbon electrode (GCE) modified with MOF derived-NiCo2O4/NiO/rGO to determine dipyridamole by differential pulse voltammetry (DPV). The NiCo2O4/NiO@MOF-5/rGO was characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction and energy-dispersive X-ray spectroscopy, map analysis, and FT-IR spectroscopic methods. The electrochemical behavior of dipyridamole at the surface of the modified electrode was investigated. After the optimization of the experimental parameters, it was shown that the designed sensor could determine dipyridamole with a limit of detection of 2.8 nM and a linear range of 0.02-550 mu M. Ultimately, the proposed sensor could determine the dipyridamole concentration in biological samples with high accuracy using certified validation in recoveries ranging from 97.7% to 104.6%.
机译：潘生丁是一种处方药，用于治疗心血管疾病、心绞痛和心肌梗死，以及心脏病患者的影像学检查。因此，需要一种高选择性、高灵敏度、低成本、高性能的快速测试来监测这种化合物。本工作基于MOF衍生的NiCo2O4/NiO/rGO修饰的玻碳电极（GCE），开发了一种灵敏、选择性和快速的电化学传感器，用微分脉冲伏安法（DPV）测定潘生丁。四氧化二镍/NiO@MOF-通过透射电子显微镜、扫描电子显微镜、X射线衍射和能量色散X射线光谱、map分析和FT-IR光谱法对5/rGO进行了表征。研究了双嘧达莫在修饰电极表面的电化学行为。优化实验参数后，结果表明，所设计的传感器可以测定双嘧达莫，检测限为2.8 nM，线性范围为0.02-550μM。最终，通过验证，所设计的传感器可以高精度地测定生物样品中的双嘧达莫浓度，回收率在97.7%到104.6%之间。

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