Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

Thapa Komal; Khan Heena; Sharma Uma; Grewal Amarjot Kaur; Singh Thakur Gurjeet

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Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

机译：聚（ADP-核糖）聚合酶-1作为神经变性疾病的有希望的药物靶标

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Aims: Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis (ALS). NAD+depletion resulted PARP related cell death only happened when the trial used extreme high oxidization treatment. Inhibition of PARP1/2 may induce replication related cell death due to un-repaired DNA damage. This review has discussed PARP-1 modulated downstream pathways in neurodegeneration and various FDA approved PARP-1 inhibitors.

机译：目的：聚ADP核糖聚合酶（PARP）-1主要由DNA损伤触发。PARP-1的过度表达与多种中枢神经系统疾病的发病机制有关，如中风、帕金森病（PD）、阿尔茨海默病（AD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS）。NAD+耗竭导致PARP相关的细胞死亡只有在试验使用极端高氧化处理时才会发生。由于未修复的DNA损伤，抑制PARP1/2可能导致复制相关的细胞死亡。这篇综述讨论了PARP-1调节神经退行性变的下游通路和各种FDA批准的PARP-1抑制剂。

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来源
《Life sciences》 |2021年第1期|共12页
作者
Thapa Komal; Khan Heena; Sharma Uma; Grewal Amarjot Kaur; Singh Thakur Gurjeet;
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作者单位

Chitkara Univ Chitkara Coll Pharm Patiala Punjab India;

Chitkara Univ Chitkara Coll Pharm Patiala Punjab India;

Chitkara Univ Chitkara Coll Pharm Patiala Punjab India;

Chitkara Univ Chitkara Coll Pharm Patiala Punjab India;

Chitkara Univ Chitkara Coll Pharm Patiala Punjab India;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
PARP (poly (ADP-ribose) polymerase); Parthanatos; Neurodegenerative diseases; PARP-1 inhibitors; Caspases; PI3K signalling; NF-kappa B signalling; ASK-JNK signalling;

机译：聚ADP核糖聚合酶;帕塔纳托斯;神经退行性疾病;PARP-1抑制剂;半胱天冬酶;PI3K信号;NF-κB信号;ASK-JNK信令;

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2. Design,synthesis,and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose)polymerase-1 and bromodomain containing protein 4 for breast cancer therapy [J] . Xiaosa Chang, Liang Ouyang, Dejuan Sun, 药学学报（英文版） . 2021,第001期
3. Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases [J] . 中国神经再生研究（英文版） . 2015,第001期
4. Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases [J] . Dagmar Pretsch 中国神经再生研究（英文版） . 2021,第012期
5. Targeting poly(ADP-ribose) polymerase-1 as a promising approach for immunomodulation in multiple sclerosis? [J] . CavoneL., ChiarugiA. Trends in molecular medicine . 2012,第2期

机译：靶向聚（ADP-核糖）聚合酶-1作为多发性硬化症中免疫调节的有前途的方法？
6. Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies. [J] . Wacker DA, Frizzell KM, Zhang T, Sub-cellular biochemistry . 2007,第0期

机译：聚（ADP-核糖）聚合酶-1对染色质结构的调节和染色质依赖性转录：药物治疗的可能目标。
7. Inhibition of poly(ADP-ribose) polymerase-1 alters expression of mitochondria-related genes in PC12 cells: relevance to mitochondrial homeostasis in neurodegenerative disorders [J] . Grzegorz A. Czapski, Magdalena Cie?lik, Przemys?aw L. Wencel, Biochimica et biophysica acta. Molecular cell research . 2018,第2期

机译：聚（ADP-核糖）聚合酶-1的抑制改变了PC12细胞中线粒体相关基因的表达：与神经变性障碍的线粒体稳态相关
8. Identification of Novel Phosphorylation Sites in Poly (ADP-Ribose) Polymerase-1 and Poly (ADP-Ribose) Glycohydrolase Using Mass Spectrometry [C] . Sylvie Bourassa, Isabelle Kelly, Jean-Philippe Gagne, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：使用质谱法鉴定聚（ADP-核糖）聚合酶-1和聚（ADP-核糖）甘油糖酶的新型磷酸化位点
9. The biophysical, biochemical and structural characterization of Poly(ADP-ribose) Polymerase-1 (PARP-1) and its complexes with DNA-damage models and chromatin substrates. [D] . Clark, Nicholas James. 2013

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10. Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1 [O] . Karine Zaniolo, Serge Desnoyers, Steeve Leclerc, 2007

机译：通过Sp1的翻译后修饰来调节聚（ADP-核糖）聚合酶-1（PARP-1）基因表达：PARP-1的核靶蛋白
11. Poly(ADP-ribose) polymerase-1 activity promotes NF-κB-driven transcription and microglial activation: implication for neurodegenerative disorders [O] . Alberto Chiarugi, Michael A. Moskowitz 2003

机译：聚（ADP-核糖）聚合酶-1活性促进NF-κB驱动的转录和微胶质激活：神经变性障碍的含义
12. Mechanisms of Poly(ADP-ribose) polymerase Catalysis; Mono-ADP-ribosylation of Poly(ADP-ribose) polymerase at Nanomolar Concentrations of NAD [R] . Bauer, P. I., Hakam, A., Kun, E. 1986

机译：聚（aDp-核糖）聚合酶催化机制;纳摩尔浓度的NaD的聚（aDp-核糖）聚合酶的单-aDp-核糖基化

Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases

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