Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway

Cheng Jie; Xu Tao; Xun Chuanhui; Guo Hailong; Cao Rui; Gao Shutao; Sheng Weibin

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Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway

机译：通过NRF2途径的激活，碳酸在暴露于整除蛋白的PC12细胞中保护碳酸溶解。

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Aims: Ferroptosis is involved in the pathogenesis of spinal cord injury (SCI). Carnosic acid (CA) is a natural phenolic diterpene, which possesses diversiform activities. However, whether the protective effect of CA on SCI is partly due to inhibition of ferroptosis was seldom investigated. Therefore, the objective of this study aimed to investigate the role of CA on ferroptosis in PC12 cells and the underlying mechanisms.

机译：目的：铁下垂参与脊髓损伤（SCI）的发病机制。鼠尾草酸（CA）是一种天然酚性二萜，具有多种活性。然而，CA对SCI的保护作用是否部分是由于抑制了铁下垂，目前很少有研究。因此，本研究旨在探讨钙在PC12细胞铁下垂中的作用及其机制。

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来源
《Life sciences》 |2021年第1期|共11页
作者
Cheng Jie; Xu Tao; Xun Chuanhui; Guo Hailong; Cao Rui; Gao Shutao; Sheng Weibin;
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作者单位

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

Xinjiang Med Univ Dept Spine Surg Affiliated Hosp 1 Urumqi 830054 Xinjiang Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Carnosic acid; Ferroptosis; PC12 cells; Nrf2; Spinal cord injury;

机译：鼠尾草酸;铁死亡PC12细胞;Nrf2;脊髓损伤;

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3. Synergism between Carnosic Acid and Arsenic Trioxide on Induction of Acute Myeloid Leukemia Cell Apoptosis Is Associated with Modulation of PTEN/Akt Signaling Pathway [J] . 王冉, 丛伟红, 郭刚, 中国结合医学杂志：英文版 . 2012,第012期
4. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway [J] . Si-tong LI, He-qing HUANG, Pei-qing LIU, 中国药理学报：英文版 . 2018,第008期
5. alpha-Lipoic acid alleviates ferroptosis in the MPP+-induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway [J] . Liu Lin, Yang Songqi, Wang Heng Cell biology international. . 2021,第2期

机译：α-脂肪酸通过激活PI3K / AKT / NRF2途径来减轻MPP +-诱导的PC12细胞中的糖凋亡
6. Carnosic Acid Protects Mitochondria of Human Neuroblastoma SH-SY5Y Cells Exposed to Paraquat Through Activation of the Nrf2/HO-1Axis [J] . Marcos Roberto de Oliveira, Alessandra Peres, Gustavo Costa Ferreira, Molecular Neurobiology . 2017,第8期

机译：通过激活NRF2 / HO-1 XIS，碳酸保护暴露于百草枯的人神经母细胞瘤SH-SEN-SEC5Y细胞的线粒体
7. Carnosic Acid Protects Mitochondria of Human Neuroblastoma SH-SY5Y Cells Exposed to Paraquat Through Activation of the Nrf2/HO-1Axis [J] . Marcos Roberto de Oliveira, Alessandra Peres, Gustavo Costa Ferreira, Molecular Neurobiology . 2017,第8期

机译：通过激活NRF2 / HO-1 XIS，碳酸保护暴露于百草枯的人神经母细胞瘤SH-SEN-SEC5Y细胞的线粒体
8. Transcription factor Nrf2 regulates adaptive cell responses towards resin monomer-induced oxidative stress through the activation of enzymatic antioxidants [C] . Helmut Schweikl, Christine Petzel, Carola Bolay, World biomaterials congress . 2016

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9. Ferroptosis: A Novel Form of Cancer Cell Death Induced by the Small Molecule Erastin [D] . Lemberg, Kathryn Marie 2011

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10. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance [O] . Nan Liu, Xiaoli Lin, Chengying Huang 2020

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11. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance [O] . Nan Liu, Xiaoli Lin, Chengying Huang 2019

机译：通过NRF2 / CBS激活反转过留率通路赋予赋予含油蛋白诱导的裂解菌抗性
12. Botulinum Toxin Type A Targets RhoB to Inhibit Lysophosphatidic Acid- Stimulated Actin Reorganization and Acetylcholine Release in PC12 Cells: A Possible Mechanism For Intervention [R] . Ishida, H. , Liao, Z. , Ray, P. 2004

机译：a型肉毒毒素靶向RhoB抑制溶血磷脂酸刺激的pC12细胞中肌动蛋白重组和乙酰胆碱释放：一种可能的干预机制

Carnosic acid protects against ferroptosis in PC12 cells exposed to erastin through activation of Nrf2 pathway

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