Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord

Leite dos Santos Gisele Graca; Lima Oliveira Anna Lethicia; Santos Dourivaldo Silva; do Espirito Santo Renan Fernandes; Silva Daniela Nascimento; Lima Juiz Paulo Jose; Pereira Soares Milena Botelho; Villarreal Cristiane Flora

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Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord

机译：间充质干细胞通过在脊髓中重新建立氧化还原稳态来减少奥沙利铂诱导的感官神经病变

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Aims: The present study was designed to investigate whether the antinociceptive effect of bone marrow-derived mesenchymal stem/stromal cells (MSC) during oxaliplatin (OXL)-induced sensory neuropathy is related to antioxidant properties.

机译：目的：本研究旨在探讨骨髓间充质干/基质细胞（MSC）在奥沙利铂（OXL）诱导的感觉神经病变中的抗伤害作用是否与抗氧化特性有关。

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来源
《Life sciences》 |2021年第1期|共10页
作者
Leite dos Santos Gisele Graca; Lima Oliveira Anna Lethicia; Santos Dourivaldo Silva; do Espirito Santo Renan Fernandes; Silva Daniela Nascimento; Lima Juiz Paulo Jose; Pereira Soares Milena Botelho; Villarreal Cristiane Flora;
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作者单位

Oswaldo Cruz Fdn FIOCRUZ Goncalo Moniz Inst BR-40296710 Salvador BA Brazil;

Oswaldo Cruz Fdn FIOCRUZ Goncalo Moniz Inst BR-40296710 Salvador BA Brazil;

Univ Fed Bahia Coll Pharm Barao de Jeremoabo S-N BR-40170115 Salvador BA Brazil;

Oswaldo Cruz Fdn FIOCRUZ Goncalo Moniz Inst BR-40296710 Salvador BA Brazil;

Univ Ctr SENAI CIMATEC SENAI Inst Innovat Adv Hlth Syst ISI SAS BR-41650010 Salvador BA Brazil;

Univ Fed Reconcavo Bahia BR-44042280 Feira De Santana BA Brazil;

Oswaldo Cruz Fdn FIOCRUZ Goncalo Moniz Inst BR-40296710 Salvador BA Brazil;

Oswaldo Cruz Fdn FIOCRUZ Goncalo Moniz Inst BR-40296710 Salvador BA Brazil;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Neuropathic pain; Chemotherapy; Mesenchymal cells; Oxidative stress; Cytokines;

机译：神经病理性疼痛;化疗间充质细胞;氧化应激;细胞因子;

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1. Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation [J] . Feng Xue, Er-jun Wu, Pei-xun Zhang, 中国神经再生研究（英文版） . 2015,第001期
2. Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injur y [J] . Zhi Li, Wei Zhao, Wei Liu, 中国神经再生研究（英文版） . 2014,第024期
3. Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy [J] . Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Stem cells international . 2021,第a期

机译：在Oxaliplatin诱导的慢性周周性神经病变中的间充质茎/基质细胞促进的伤害初级传入中的赤脂母细胞的重新建立氧化还原骨囊
4. Reduced inflammatory cell recruitment and tissue damage in spinal cord injury by acellular spinal cord scaffold seeded with mesenchymal stem cells [J] . Wang Yu-Hai, Chen Jian, Zhou Jing, Experimental and therapeutic medicine . 2017,第1期

机译：用间充质干细胞播种脊髓支架血管损伤的炎症细胞招生和组织损伤
5. Vascular Endothelial Growth Factor-Transfected Bone Marrow Mesenchymal Stem Cells Improve the Recovery of Motor and Sensory Functions of Rats With Spinal Cord Injury [J] . Liu Xiao, Xu Wenqi, Zhang Zhengzheng, Spine . 2020,第7期

机译：血管内皮生长因子转染的骨髓间充质干细胞改善了脊髓损伤大鼠电机和感官功能的回收率
6. Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma [C] . Lianyuan Feng, Aruna Sharma, Feng Niu, Annual techconnect world innovation conference expo . 2018

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7. Transplantation of adult neural stem/progenitor cells and bone marrow derived mesenchymal stromal cells in the injured adult rat spinal cord. [D] . Parr, Ann Margaret. 2007

机译：成年神经干/祖细胞和骨髓源性间充质基质细胞在成年大鼠脊髓中的移植。
8. Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic Peripheral Neuropathy [O] . Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, 2021

机译：在Oxaliplatin诱导的慢性周周性神经病变中的间充质茎/基质细胞促进的伤害初级传入中的赤脂母细胞的重新建立氧化还原骨囊
9. Early transplantation of mesenchymal stem cells after spinal cord injury relieves pain hypersensitivity through suppression of pain-related signaling cascades and reduced inflammatory cell recruitment [O] . Watanabe, Shuji, Uchida, Kenzo, Nakajima, Hideaki, 2015

机译：脊髓损伤后间充质干细胞的早期移植通过抑制与疼痛有关的信号传导级联和减少炎症细胞募集而缓解了疼痛超敏反应
10. Autologous Marrow-Derived Stem Cell-Seeded Gene-Supplemented Collagen Scaffolds for Spinal Cord Regeneration as a Treatment for Paralysis [R] . Spector, M. 2009

机译：自体骨髓来源的干细胞接种基因补充胶原支架用于脊髓再生治疗瘫痪

Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord

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