Silencing SGK1 alleviates osteoarthritis through epigenetic regulation of CREB1 and ABCA1 expression

Wang Zheng; Ni Shuangfei; Zhang Huafeng; Fan Yonggang; Xia Lei; Li Ning

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Silencing SGK1 alleviates osteoarthritis through epigenetic regulation of CREB1 and ABCA1 expression

机译：沉默的SGK1通过CREB1和ABCA1表达的表观遗传调节来减轻骨关节炎

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Aim: Osteoarthritis (OA) is the most common joint disorder and a leading cause of disability. While early proactive management is crucial in alleviating symptoms in OA patients, currently available therapeutic approaches are yet to achieve an ideal level of efficacy. The path to the development of a potent treatment begins with the thorough understanding of the pathophysiology of OA. The present study aims to explore the mechanism by which SGK1 is involved in OA progression.

机译：目的：骨关节炎（OA）是最常见的关节疾病，也是致残的主要原因。虽然早期主动治疗对于缓解OA患者的症状至关重要，但目前可用的治疗方法尚未达到理想的疗效水平。有效治疗的发展之路始于对OA病理生理学的透彻理解。本研究旨在探讨SGK1参与OA进展的机制。

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来源
《Life sciences》 |2021年第1期|共8页
作者
Wang Zheng; Ni Shuangfei; Zhang Huafeng; Fan Yonggang; Xia Lei; Li Ning;
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作者单位

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

Zhengzhou Univ Dept Orthopaed Affiliated Hosp 1 1 Eastern Jianshe Rd Zhengzhou 450000 Henan;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
SGK1; CREB1; ABCA1; Osteoarthritis; Apoptosis; Proliferation; Inflammation;

机译：SGK1;CREB1;ABCA1;骨关节炎;凋亡;激增发炎;

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Silencing SGK1 alleviates osteoarthritis through epigenetic regulation of CREB1 and ABCA1 expression

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