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The modulation of the spatial reference memory by the orexinergic system of the dorsal raphe nucleus

机译：背甲核的骨膜能系统对空间参考记忆的调节

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The dorsal raphe nucleus (DRN) is a brainstem nucleus involved in the pathophysiology of the depression, through its semtoninergic innervation. Furthermore, depressive symptoms in patients are also associated with some memory and sleep complaints. Anatomical evidence confirmed the presence of projections from the lateral hypothalamus to semtonergic neurons of the dorsal raphe nucleus (DRN). These projection fibers release orexin neuropeptides which play roles in the spatial memory. Both of the orexinergic receptors are widely distributed in dorsal raphe nucleus. Therefore, the present work was aimed to assess the probable roles of orexin 1 and 2 receptors using an orexin 1 receptor antagonist, SB-334867-A, and an orexin 2 receptor antagonist, TCS-OX2-29 in the DRN on the retrieval, and consolidation phases of spatial reference memory in the Morris water maze (MWM) task. The results demonstrated that blocking orexin 1 receptors in the DRN impairs the process of memory consolidation in the spatial MWM via increasing in the time of the escape latency of the probe day. Blocking these receptors did not affect the retrieval phase of MWM learning. Furthermore, blocking of the orexin 2 receptors in this area did not affect neither consolidation nor retrieval phases of the memory. In conclusion, orexin 1 receptors in the DRN play major roles in the consolidation of the spatial reference memory in rats.
机译：中缝背核（DRN）是一个脑干核，通过其半色调能神经支配参与抑郁症的病理生理。此外，患者的抑郁症状也与一些记忆和睡眠问题有关。解剖学证据证实存在从下丘脑外侧到中缝背核（DRN）半音能神经元的投射。这些投射纤维释放食欲素神经肽，在空间记忆中发挥作用。这两种食欲素受体广泛分布于中缝背核。因此，本研究旨在使用食欲素1受体拮抗剂SB-334867-A和食欲素2受体拮抗剂TCS-OX2-29评估DRN中食欲素1和2受体在莫里斯水迷宫（MWM）任务中空间参考记忆的恢复和巩固阶段的可能作用。结果表明，阻断DRN中的orexin 1受体会通过增加探测日的逃逸潜伏期而损害空间MWM中的记忆巩固过程。阻断这些受体不会影响MWM学习的恢复阶段。此外，阻断该区域的食欲素2受体既不影响记忆的巩固阶段，也不影响记忆的恢复阶段。总之，DRN中的食欲素1受体在大鼠空间参考记忆的巩固中起主要作用。

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