Possible mechanism and potential application of anti-opioid effect of diazepam-binding inhibitor

Qin Wangjun; Qu Hong; Pan Lin; Sun Weiliang; Chen Yuzhen; Wu Caihong

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Possible mechanism and potential application of anti-opioid effect of diazepam-binding inhibitor

机译：二氮酸泮结合抑制剂抗阿片类药物的可能机制及潜在应用

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Aims: Our previous study has demonstrated that porcine diazepam-binding inhibitor (pDBI) and its active fragments, pDBI-16 and pDBI-19, have inhibition effect on morphine analgesia in mice. The present study aimed to investigate the underlying mechanism and potential application of this anti-opioid effect.

机译：目的：我们之前的研究表明，猪地西泮结合抑制剂（pDBI）及其活性片段pDBI-16和pDBI-19对小鼠吗啡镇痛有抑制作用。本研究旨在探讨这种抗阿片效应的潜在机制和潜在应用。

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来源
《Life sciences》 |2021年第1期|共7页
作者
Qin Wangjun; Qu Hong; Pan Lin; Sun Weiliang; Chen Yuzhen; Wu Caihong;
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作者单位

China Japan Friendship Hosp Dept Pharm Beijing 100029 Peoples R China;

Peking Univ Coll Life Sci Ctr Bioinformat State Key Lab Prot &

Plant Gene Res Beijing 100871;

China Japan Friendship Hosp Inst Clin Med Sci Beijing 100029 Peoples R China;

China Japan Friendship Hosp Inst Clin Med Sci Beijing 100029 Peoples R China;

China Japan Friendship Hosp Inst Clin Med Sci Beijing 100029 Peoples R China;

Peking Univ State Key Lab Membrane Biol Beijing 100871 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Diazepam-binding inhibitor; Anti-opioid; Lateral habenular; NMDA receptor; NO;

机译：地西泮结合抑制剂;抗阿片类药物;外侧缰;NMDA受体;不;

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Possible mechanism and potential application of anti-opioid effect of diazepam-binding inhibitor

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