Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut induced carcinogenesis in female mice

Nath Moumita; Bhattacharjee Kasturi; Choudhury Yashmin

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Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut induced carcinogenesis in female mice

机译：二肽基肽酶-4抑制剂vildagliptin，减少了雌性小鼠的Betel-nut诱发的致癌物

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Aim: Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-4 inhibitor, for alleviating the oncogenic condition in female Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml(-1)) for 24 weeks.

机译：目的：槟榔是东南亚人群中流行的咀嚼品，是一种I类致癌物，以前与血脂异常和脂质代谢异常有关，据报道，女性比男性更频繁地使用槟榔。这项研究调查了抗糖尿病药物vildagliptin（二肽基肽酶-4抑制剂）的潜在用途，以减轻口服槟榔水提取物（AEBN）24周的雌性瑞士白化小鼠的致癌状况。

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来源
《Life sciences》 |2021年第1期|共13页
作者
Nath Moumita; Bhattacharjee Kasturi; Choudhury Yashmin;
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作者单位

Assam Univ Dept Biotechnol Silchar 788011 Assam India;

Assam Univ Dept Biotechnol Silchar 788011 Assam India;

Assam Univ Dept Biotechnol Silchar 788011 Assam India;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Akt-mTOR; AMPK signaling; Betel-nut; Carcinogenesis; Drug repurposing; Vildagliptin;

机译：Akt mTOR;AMPK信号;槟榔;致癌作用;重新调整药物用途;维尔达格利平;

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Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut induced carcinogenesis in female mice

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