Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis

de Santiago Pamela R.; Blanco Alejandro; Morales Fernanda; Marcelain Katherine; Harismendy Olivier; Herrera Marcela Sjoberg; Armisen Ricardo

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Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis

机译：免疫相关的Inclna linc00944响应ADAR1水平的变化，它与乳腺癌预后有关

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Aims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) is upregulated in breast cancer, predicting poor prognosis in patients. A few reports in literature examine ADAR1 and long non-coding RNAs (lncRNAs) interplay in cancer and suggest key roles in cancer-related pathways. This study aimed to investigate whether ADAR1 could alter the expression levels of lncRNAs and explore how those changes are related to breast cancer biology.

机译：目的：乳腺癌是全球女性死亡的主要原因之一，是一个主要的公共卫生问题。据报道，作用于RNA 1的RNA编辑酶腺苷脱氨酶（ADAR1）在乳腺癌中的表达上调，预测患者预后不良。文献中的一些报告研究了ADAR1和长非编码RNA（lncRNAs）在癌症中的相互作用，并提出了在癌症相关途径中的关键作用。本研究旨在调查ADAR1是否能改变lncRNAs的表达水平，并探讨这些变化与乳腺癌生物学的关系。

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来源
《Life sciences》 |2021年第1期|共11页
作者
de Santiago Pamela R.; Blanco Alejandro; Morales Fernanda; Marcelain Katherine; Harismendy Olivier; Herrera Marcela Sjoberg; Armisen Ricardo;
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作者单位

Pontificia Univ Catolica Chile Fac Ciencias Biol Dept Biol Celular &

Mol Av Libertador Bernardo;

Pfizer Chile Ctr Excellence Precis Med Santiago Chile;

Pfizer Chile Ctr Excellence Precis Med Santiago Chile;

Univ Chile Fac Med Ctr Invest &

Tratamiento Canc Santiago Chile;

Univ Calif San Diego Dept Med Div Biomed Informat La Jolla CA 92093 USA;

Pontificia Univ Catolica Chile Fac Ciencias Biol Dept Biol Celular &

Mol Av Libertador Bernardo;

Univ Desarrollo Fac Med Clin Alemana Inst Ciencias &

Innovac Med Ctr Genet &

Genom Av Las;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Breast cancer; Cancer; lncRNAs; LINC00944; ADAR1; Prognosis; Tumor-infiltrating lymphocytes; Bioinformatics; Guilt by association analysis;

机译：乳腺癌;巨蟹座lncRNAs;LINC00944;ADAR1;预后肿瘤浸润淋巴细胞;生物信息学;犯罪关联分析;

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专利

1. Evaluation of the prognosis as well as tumor marker levels and immune function of Fuzheng Xiaoliu decoction combined with paclitaxel treatment of advanced breast cancer [J] . Hai-Ping Huang, Jin-Ru Zhang, Xiao-Fang Li, 海南医科大学学报（英文版） . 2016,第020期
2. A meta-analysis of the prognosis in patients with breast cancer with ipsilateral supraclavicular lymph node metastasis versus patients with stage Ⅲb/c or Ⅳ breast cancer [J] . Xu-Hong Liu, Lei Zhang, Bo Chen 慢性疾病与转化医学（英文） . 2015,第004期
3. Breast—— Expression of CK5/6 and CK17 and its correlation with prognosis of triple-negative breast cancer patients [J] . 刘哲斌中国医学文摘：外科学分册英文版 . 2008,第004期
4. Immune-related gene data-based molecular subtyping related to the prognosis of breast cancer patients [J] . Guoyu Mu, Hong Ji, Hui He, Breast cancer . 2021,第2期

机译：基于免疫相关基因数据的分子亚型与乳腺癌患者的预后相关
5. An immune-related signature that to improve prognosis prediction of breast cancer [J] . Yi Zhang, Xuebing Di, Guoji Chen, American Journal of Cancer Research . 2021,第4期

机译：改善乳腺癌预后预测的免疫相关签名
6. Identification of an immune-related long noncoding RNA signature that predicts prognosis in breast cancer patients [J] . Li Na, Li Zubin, Li Xin, Biomarkers in medicine . 2021,第3期

机译：鉴定免疫相关的长型Noncoding RNA签名，其预测乳腺癌患者预后
7. Prognosis prediction of human breast cancer by integrating deep neural network and support vector machine: Supervised feature extraction and classification for breast cancer prognosis prediction [C] . Dongdong Sun, Minghui Wang, Huanqing Feng, International Congress on Image and Signal Processing, BioMedical Engineering and Informatics . 2017

机译：集成深度神经网络和支持向量机的人类乳腺癌预后预测：乳腺癌预后预测的有监督特征提取和分类
8. Analyses of Select Immune-Related and Other Genes Associated with Triple Negative Breast Cancer and Other Breast Tissue [D] . Harris Jr., Anthony G. 2018

机译：与三重阴性乳腺癌和其他乳腺组织相关的选择免疫相关和其他基因的分析
9. An immune-related signature that to improve prognosis prediction of breast cancer [O] . Yi Zhang, Xuebing Di, Guoji Chen, 2021

机译：改善乳腺癌预后预测的免疫相关签名
10. Novel Immune-Related Gene Signature for Risk Stratification and Prognosis of Survival in Estrogen Receptor (ER) or Progesterone Receptor (PR) Positive and Human Epidermal Growth Factor Receptor 2 (HER2) Negative Breast Cancer [O] . Wei Wang, Hongnan Jiang, Yanrong Gao 2021

机译：用于雌激素受体（ER）或孕激素受体（PR）阳性和人表皮生长因子受体2（HER2）阴性乳腺癌的风险分层和预后的新型免疫相关基因签名
11. Can Exosomes Induced by Breast Involution Be Markers for the Poor Prognosis and Prevention of Post-partum Breast Cancer. [R] . Borges, V. F. 2016

机译：乳腺内卷入引起的外泌体可以作为乳腺癌预后不良和预防的标志物。

Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis

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