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Progress of non-coding RNAs in triple-negative breast cancer

机译：三重阴性乳腺癌中非编码RNA的进展

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摘要

Non-coding RNAs (ncRNAs) include miRNA, lncRNA, and circRNA. NcRNAs are involved in multiple biological processes, including chromatin remodeling, signal transduction, post-transcriptional modification, cell autophagy, carbohydrate metabolism, and cell cycle regulation. Triple negative breast cancer (TNBC) is notorious for high invasiveness and metastasis, poor prognosis, and high mortality, and it is the most malignant breast cancer, while the effective targets for TNBC treatment are still lacking. NcRNAs act as oncogenes or suppressor genes, as well as promote or inhibit the occurrence and development of TNBC. Here, we reviewed some important miRNAs, lncRNAs, circRNAs, their target(s) and molecular mechanisms in TNBC. It is benefited to understand the occurrence and development of TNBC, further some ncRNAs might be potential targets for TNBC treatment.
机译：非编码RNA（NCRNA）包括miRNA、lncRNA和circRNA。NcRNAs参与多种生物学过程，包括染色质重塑、信号转导、转录后修饰、细胞自噬、碳水化合物代谢和细胞周期调节。三阴性乳腺癌（Triple negative breast cancer，TNBC）以其高侵袭性、高转移性、预后差、高死亡率而臭名昭著，是最恶性的乳腺癌，但TNBC治疗的有效靶点仍然缺乏。NcRNAs作为癌基因或抑制基因，促进或抑制TNBC的发生和发展。在这里，我们回顾了一些重要的miRNAs，lncRNAs，circRNAs，它们在TNBC中的靶点和分子机制。有助于了解TNBC的发生和发展，而且一些ncRNAs可能是TNBC治疗的潜在靶点。

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  • 来源
    《Life sciences》 |2021年第1期|共13页
  • 作者

    Liu Jie; Zhao Gang; Liu Xin-Li; Zhang Ge; Zhao Shi-Qi; Zhang Shi-Long; Luo Li-Heng; Yin Da-Chuan; Zhang Chen-Yan;

  • 作者单位

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    First Hosp Jilin Univ Breast Surg Changchun 130021 Jilin Peoples R China;

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

    Northwestern Polytech Univ Sch Life Sci Inst Special Environm Biophys Key Lab Space Biosci &

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 医药、卫生;
  • 关键词

    Triple-negative breast cancer; Non-coding RNA; miRNA; lncRNA; circRNA;

    机译：三阴性乳腺癌;非编码RNA;miRNA;lncRNA;circRNA;

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