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Recent trends in cancer therapy: A review on the current state of gene delivery

机译：近期癌症治疗的趋势：关于基因交付状态的综述

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摘要

Cancer treatment has been always considered one of the most critical and vital themes of clinical issues. Many approaches have been developed, depending on the type and the stage of tumor. Gene therapy has the potential to revolutionize different cancer therapy. With the advent of recent bioinformatics technologies and genetic science, it become possible to identify, diagnose and determine the potential treatment using the technology of gene delivery. Several approaches have been developed and experimented in vitro and vivo for cancer therapy including: naked nucleic acids based therapy, targeting micro RNAs, oncolytic virotherapy, suicide gene based therapy, targeting telomerase, cell mediated gene therapy, and CRISPR/Cas9 based therapy. In this review, we present a straightforward introduction to cancer biology and occurrence, highlighting different viral and non-viral gene delivery systems for gene therapy and critically discussed the current and various strategies for cancer gene therapy.
机译：癌症治疗一直被认为是临床问题中最关键和最重要的主题之一。根据肿瘤的类型和分期，已经开发了许多方法。基因治疗有可能彻底改变不同的癌症治疗。随着最近生物信息学技术和基因科学的出现，利用基因传递技术识别、诊断和确定潜在治疗成为可能。有几种癌症治疗方法已经在体外和体内开发和实验，包括：基于裸核酸的治疗、靶向微RNA、溶瘤病毒治疗、基于自杀基因的治疗、靶向端粒酶、细胞介导的基因治疗和基于CRISPR/Cas9的治疗。在这篇综述中，我们简单介绍了癌症的生物学和发生，重点介绍了用于基因治疗的不同病毒和非病毒基因传递系统，并批判性地讨论了癌症基因治疗的当前和各种策略。

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