MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

Cao Xin; Xue Li-Dan; Di Yue; Li Tao; Tian Ya-Jing; Song Yu

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MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

机译：MSC衍生的外泌体LNCRNA SNHG7通过MIR-34A-5P / XBP1轴抑制糖尿病视网膜病变中的内皮 - 间充质转变和管形成

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Aims: Diabetic retinopathy (DR) is the most common complication of type 2 diabetes mellitus, which could result in visual impairment. Accumulating studies have shown the implication of long non-coding RNAs (lncRNAs) in the pathogenesis of DR. Our aims are to investigate whether lncRNA SNHG7 plays a role during DR pathogenesis.

机译：目的：糖尿病视网膜病变（DR）是2型糖尿病最常见的并发症，可导致视力损害。越来越多的研究表明，长非编码RNA（lncRNAs）在DR的发病机制中具有重要意义。我们的目的是研究lncRNA SNHG7是否在DR的发病机制中发挥作用。

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来源
《Life sciences》 |2021年第1期|共12页
作者
Cao Xin; Xue Li-Dan; Di Yue; Li Tao; Tian Ya-Jing; Song Yu;
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作者单位

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

Nantong Univ Affiliated Hosp 2 Dept Ophthalmol 6 Haierxiang North Rd Nantong 226000 Jiangsu;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Diabetic retinopathy; SNHG7; miR-34a-5p; XBP1; Exosome; Mesenchymal stem cells;

机译：糖尿病性视网膜病变;SNHG7;miR-34a-5p;XBP1;外体;间充质干细胞;

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外文文献

1. LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis [J] . Tian Feng, Wang Junhu, Zhang Zhanhua, Biological research: BR . 2020,第a期

机译：LNCRNA SNHG7 / MIR-34A-5P / SYVN1轴在骨关节炎的增殖，细胞凋亡和自噬中起着至关重要的作用
2. DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway [J] . Y. He, Y. Dan, X. Gao, American Journal of Physiology . 2021,第3Pta1期

机译：DNMT1介导的LNCRNA MEG3甲基化通过PI3K / AKT / MTOR信号通路加速糖尿病视网膜病变中的内皮 - 间充质转变
3. Knockdown of LncRNA SNHG7 inhibited epithelial-mesenchymal transition in prostate cancer though miR-324-3p/WNT2B axis in vitro [J] . han Yangyang, Hu Haibo, zhou jinsong Pathology Research and Practice . 2019,第10期

机译：LNCRNA SNHG7的敲低虽然MIR-324-3P / WNT2B轴在体外抑制前列腺癌中的上皮 - 间充质转变
4. LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation apoptosis and autophagy in osteoarthritis [O] . Feng Tian, Junhu Wang, Zhanhua Zhang, 2020

机译：LncRNA SNHG7 / miR-34a-5p / SYVN1轴在骨关节炎的增殖凋亡和自噬中起重要作用
5. LncRNA XIST knockdown suppresses cell proliferation and promotes apoptosis in diabetic cataract via miR-34a/SMAD2 axis [O] . Chao Wang, Ruiling Zhao, Suhong Zhang 2021

机译：LNCRNA XIST敲低抑制细胞增殖，并通过MIR-34A / SMAD2轴促进糖尿病白内障的细胞凋亡

MSC-derived exosomal lncRNA SNHG7 suppresses endothelial-mesenchymal transition and tube formation in diabetic retinopathy via miR-34a-5p/XBP1 axis

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