LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer

Hou Yanjiao; Jia Hengmin; Cao Yanhong; Zhang Shuang; Zhang Xiaolei; Wei Pingping; Xie Jun; Dong Wenqian; Wang Baolong

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LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer

机译：通过在非小细胞肺癌中激活Ang2 / Tie2轴来促进肿瘤血管生成促进肿瘤血管生成

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Aims: Non-small cell lung cancer (NSCLC) is considered a highly fatal tumor. Importantly, angiogenesis is critical for tumor progression. Long non-coding RNAs (lncRNAs), which are untranslatable, control cell functions through different pathways. lncRNA EPIC1 has been reported to promote cell viability, cell cycle progression, and invasion. However, the relationship between EPIC1 and tumor angiogenesis remains an enigma. We explored the role of EPIC1 in tumor angiogenesis in NSCLC.

机译：目的：非小细胞肺癌（NSCLC）被认为是一种高度致命的肿瘤。重要的是，血管生成对肿瘤进展至关重要。长非编码RNA（lncRNAs）不可翻译，通过不同途径控制细胞功能。据报道，lncRNA EPIC1可促进细胞活力、细胞周期进展和侵袭。然而，EPIC1与肿瘤血管生成之间的关系仍然是一个谜。我们探讨了EPIC1在NSCLC肿瘤血管生成中的作用。

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来源
《Life sciences》 |2021年第1期|共12页
作者
Hou Yanjiao; Jia Hengmin; Cao Yanhong; Zhang Shuang; Zhang Xiaolei; Wei Pingping; Xie Jun; Dong Wenqian; Wang Baolong;
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作者单位

Shandong Univ Cheeloo Coll Med Sch Med Jinan 253000 Shandong Peoples R China;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Anhui Med Univ Affliated Anhui Prov Hosp Dept Clin Lab Hefei 230000 Anhui Peoples R China;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

Univ Sci &

Technol China Div Life Sci &

Med Affiliated Hosp USTC 1 Dept Clin Lab Hefei 230001;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
lncRNA EPIC1; Angiogenesis; Co-culture; Ang2/Tie2; NSCLC;

机译：lncRNA EPIC1;血管生成;共培养;Ang2/Tie2;非小细胞肺癌;

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专利

1. Effects of recombinant human endostatin on therapeutic effect, angiogenesis, tumor cell proliferation and migration in patients with non-small cell lung cancer [J] . Min-Wen Ling, Jie Wang, Hong-Zi Ding 海南医科大学学报（英文版） . 2019,第002期
2. Effects of recombinant human endostatin on therapeutic effect, angiogenesis, tumor cell proliferation and migration in patients with non-small cell lung cancer [J] . Min-Wen Ling, Jie Wang, Hong-Zi Ding 海南医科大学学报(英文版) . 2019,第002期
3. Correlation study between CT perfusion parameters of non-small cell lung cancer and angiogenesis, cell proliferation as well as tumor load [J] . Fa-Hong Lin 海南医科大学学报（英文版） . 2017,第002期
4. Correlation study between CT perfusion parameters of non-small cell lung cancer and angiogenesis, cell proliferation as well as tumor load [J] . Fa-Hong Lin 海南医科大学学报(英文版) . 2017,第002期
5. Activation of Toll-like receptors signaling in non-small cell lung cancer cell line induced by tumor-associated macrophages [J] . Xing Ke, Meng Wu, Jianfang Lou, 中国癌症研究（英文版） . 2015,第002期
6. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. [J] . Mazzieri R, Pucci F, Moi D, Cancer Cell . 2011,第4期

机译：靶向ANG2 / TIE2轴可通过削弱血管生成并禁用促血管生成髓样细胞的反弹来抑制肿瘤生长和转移。
7. LncRNA MEG8 promotes tumor progression of non-small cell lung cancer via regulating miR-107/CDK6 axis [J] . Ying Liu, Lei Li, Peng Shang, Anti-cancer drugs . 2020,第10期

机译：LNCRNA MEG8通过调节miR-107 / cdk6轴来促进非小细胞肺癌的肿瘤进展
8. Up-Regulation of FSTL3, Regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, Promotes Proliferation and Migration of Non-Small Cell Lung Cancer Cells [J] . Liang Gao, Xiaochen Chen, Yongxiang Wang, OncoTargets and therapy . 2020,第2期

机译：FSTL3的上调，由LNCRNA DSCAM-AS1 / miR-122-5P轴调节，促进非小细胞肺癌细胞的增殖和迁移
9. Angiogenesis in the Treatment of Non-Small Cell Lung Cancer [C] . Leora Horn, Alan B.Sandler 21st international conference on screening for lung cancer . 2009

机译：血管生成治疗非小细胞肺癌
10. Targeting the Notch-1/IGF-1R/Akt axis in an orthotopic model of advanced non-small cell lung cancer [D] . Liang, Shuang 2013

机译：在晚期非小细胞肺癌原位模型中靶向Notch-1 / IGF-1R / Akt轴
11. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer [O] . Hanli Fan, Jianbo Li, Jiwu Wang, 2019

机译：长非编码RNA（lncRNAs）lncRNA在染色体8p12（TSLNC8）上的肿瘤抑制作用通过调节白介素6（IL-6）/信号转导子和转录激活因子3（STAT3）/低氧诱导剂来抑制肿瘤转移并促进细胞凋亡。非小细胞肺癌中的因子1-alpha（HIF-1α）信号通路
12. Long Non-Coding RNAs (lncRNAs) Tumor-Suppressive Role of lncRNA on Chromosome 8p12 (TSLNC8) Inhibits Tumor Metastasis and Promotes Apoptosis by Regulating Interleukin 6 (IL-6)/Signal Transducer and Activator of Transcription 3 (STAT3)/Hypoxia-Inducible Factor 1-alpha (HIF-1α) Signaling Pathway in Non-Small Cell Lung Cancer [O] . Hanli Fan, Jianbo Li, Jiwu Wang, 2019

机译：LNCRNA在染色体上的长期非编码RNA（LNCRNA）肿瘤抑制作用抑制肿瘤转移，并通过调节白细胞介素6（IL-6）/信号传感器和转录3（STAT3）/缺氧诱导的激活剂来促进细胞凋亡非小细胞肺癌中的因子1-α（HIF-1α）信号传导途径
13. Role of CDK5 as a Tumor Suppressor Gene in Non-Small Cell Lung Cancer. [R] . Nelkin, B. D. 2014

机译：CDK5在非小细胞肺癌中作为肿瘤抑制基因的作用。

LncRNA EPIC1 promotes tumor angiogenesis via activating the Ang2/Tie2 axis in non-small cell lung cancer

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