Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

Yuan Chong; Wang Meng-Heng; Wang Fei; Chen Peng-Yu; Ke Xin-Ge; Yu Bing; Yang Yan-Fang; You Peng-Tao; Wu He-Zhen

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Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

机译：网络药理学和分子对接揭示了微氨基对非小细胞肺癌的机制

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Aims: Scopoletin is a natural anticarcinogenic and antiviral coumarin component. Many studies have proved its anti-cancer effect, and after the preliminary screening of this study, Scopoletin had the best inhibitory effect on Non-small cell lung cancer (NSCLC). But its mechanism for treating NSCLC is still unclear. Therefore, network pharmacology and molecular docking technology were used to explore the potential anti-NSCLC targets and pathways of Scopoletin. The results were verified in vitro.

机译：目的：东莨菪内酯是一种天然的抗癌和抗病毒香豆素成分。许多研究已经证明了其抗癌作用，在本研究的初步筛选后，东莨菪内酯对非小细胞肺癌（NSCLC）的抑制效果最好。但其治疗非小细胞肺癌的机制尚不清楚。因此，网络药理学和分子对接技术被用来探索东莨菪内酯潜在的抗NSCLC靶点和途径。结果在体外得到验证。

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来源
《Life sciences》 |2021年第1期|共11页
作者
Yuan Chong; Wang Meng-Heng; Wang Fei; Chen Peng-Yu; Ke Xin-Ge; Yu Bing; Yang Yan-Fang; You Peng-Tao; Wu He-Zhen;
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作者单位

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

Hubei Univ Chinese Med Fac Pharm Wuhan 430065 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Scopoletin; NSCLC; Network pharmacology; Mechanism of action; Molecular docking; In vitro;

机译：东莨菪碱;非小细胞肺癌;网络药理学;作用机制;分子对接;体外培养;

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Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

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