Oxysophocarpine suppresses FGFR1-overexpressed hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib

Zhao Zhongwei; Song Jingjing; Zhang Dengke; Wu Fazong; Tu Jianfei; Ji Jiansong

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Oxysophocarpine suppresses FGFR1-overexpressed hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib

机译：oxysophocarpine抑制FGFR1过表达的肝细胞癌生长，并敏感Lenvatinib的治疗效果

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Aims: Hepatocellular carcinoma (HCC) is an aggressive solid tumor with restricted therapeutics. Lenvatinib is the second approved frontline drug for advanced HCC, however lenvatinib-resistant cases have been reported in clinical. Overexpression of fibroblast growth factor receptor (FGFR1) has been found to be associated with advanced HCC. This study was aimed to investigate the relationship between FGFR1 overexpression and lenvatinib resistance, and explore the potential candidate that can sensitize lenvatinib against FGFR1-overexpressed HCC.

机译：目的：肝细胞癌（HCC）是一种侵袭性实体瘤，治疗手段有限。伦伐替尼是第二种获准用于晚期肝癌的一线药物，但临床上已有伦伐替尼耐药病例报告。已发现成纤维细胞生长因子受体（FGFR1）的过度表达与晚期肝癌相关。本研究旨在研究FGFR1过度表达与lenvatinib耐药性之间的关系，并探索lenvatinib对FGFR1过度表达HCC的潜在致敏候选药物。

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来源
《Life sciences》 |2021年第1期|共11页
作者
Zhao Zhongwei; Song Jingjing; Zhang Dengke; Wu Fazong; Tu Jianfei; Ji Jiansong;
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作者单位

Zhejiang Univ Wenzhou Med Univ Affiliated Lishui Hosp Cent Hosp Zhejiang Lishui Affiliated Hosp;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Oxysophocarpine; Hepatocellular carcinoma; Lenvatinib; FGFR1;

机译：氧化槐果碱;肝细胞癌;伦瓦蒂尼;FGFR1;

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1. MicroRNA-449a suppresses hepatocellular carcinoma cell growth via G1 phase arrest and the HGF/MET c-Met pathway [J] . Jun Cheng, Li-Ming Wu, Xue-Song Deng, 国际肝胆胰疾病杂志（英文版） . 2018,第004期
2. Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression [J] . Jianchu Wang, Wang Wei, Qianli Tang, Cancer Medicine . 2020,第19期

机译：oxysophocarpine抑制肝细胞癌生长，并通过减少FGL1表达敏感抗滞后-3的治疗障碍
3. Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression [J] . Zhongwei Zhao, Dengke Zhang, Fazong Wu, Journal of cellular and molecular medicine. . 2021,第1期

机译：通过抑制 RAS / MEK / ERK 槐禁止显示 lenvatinib 耐肝细胞癌生长通过降低 VEGFR2 表达轴线
4. Therapeutic efficacy of lenvatinib in nonviral unresectable hepatocellular carcinoma [J] . Tetsu Tomonari, Yasushi Sato, Hironori Tanaka, JGH OPEN . 2021,第11期

机译：Lenvatinib在非血管不可切除的肝细胞癌中的治疗疗效
5. Reducible Poly(Oligo Oligo-D-Arginine) for Delivery of elivery Vascular Endothelial Growth Factor siRNAEffectively Suppresses Growth of Squamous Cell Carcinoma [C] . Young -Wook Won, Yong -Hee Kim Annual meeting exposition of the Controlled Release Society . 2009

机译：可还原的聚（Oligo Oligo-D-精氨酸）交付交付的血管内皮生长因子siRNA有效抑制鳞状细胞癌的生长。
6. Super Enhancer-associated Master Transcription Factor SOX4 Suppresses Anti-tumor Immunity in NAFLD-associated Hepatocellular Carcinoma [D] . Cheung, Ka Wing. 2019

机译：超强增强剂相关的母转录因子SOx4抑制NAFLD相关肝细胞癌中的抗肿瘤免疫力
7. Oxysophocarpine suppresses hepatocellular carcinoma growth and sensitizes the therapeutic blockade of anti‐Lag‐3 via reducing FGL1 expression [O] . Jianchu Wang, Wang Wei, Qianli Tang, 2020

机译：oxysophocarpine抑制肝细胞癌生长并通过减少FGL1表达敏感抗滞后-3的治疗障碍
8. Evaluating the therapeutic effect of lenvatinib against advanced hepatocellular carcinoma by measuring blood flow changes using contrast‐enhanced ultrasound [O] . Naoki Kamachi, Masahito Nakano, Shusuke Okamura, 2021

机译：使用对比度增强超声测量血流变化来评估Lenvatinib对晚期肝细胞癌的治疗效果
9. Partial Purification and Characterization of a Hepatocyte Growth Factor Produced by Rat Hepatocellular Carcinoma Cells [R] . Luetteke, N. C. , Michalopoulos, G. K. 1985

机译：大鼠肝癌细胞产生肝细胞生长因子的部分纯化与鉴定

Oxysophocarpine suppresses FGFR1-overexpressed hepatocellular carcinoma growth and sensitizes the therapeutic effect of lenvatinib

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