Astaxanthin inhibits microglia M1 activation against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-31-5p

Zhou Xin; Zhang Junyu; Li Yuxin; Cui Liao; Wu Kefeng; Luo Hui

首页> 外文期刊>Life sciences >Astaxanthin inhibits microglia M1 activation against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-31-5p

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Astaxanthin inhibits microglia M1 activation against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-31-5p

机译：虾青素抑制Microglia M1激活对脂多糖引发的抗炎损伤通过下调miR-31-5p

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摘要

Aims: Astaxanthin is a natural carotenoid, can readily cross the blood-brain barrier and exerts a powerful neuroprotective effect. In this study, experiments were performed to explore the underlying molecular mechanisms of which Astaxanthin inhibiting the microglia M1 activation.

机译：目的：虾青素是一种天然类胡萝卜素，可轻易穿过血脑屏障，并发挥强大的神经保护作用。本研究旨在探索虾青素抑制小胶质细胞M1激活的分子机制。

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来源
《Life sciences》 |2021年第1期|共10页
作者
Zhou Xin; Zhang Junyu; Li Yuxin; Cui Liao; Wu Kefeng; Luo Hui;
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作者单位

Guangdong Med Univ Marine Biomed Res Inst 2 Wenming Dong Rd Zhanjiang 524023 Guangdong Peoples;

Guangdong Med Univ Dept Pharmacol Zhanjiang 524023 Peoples R China;

Guangdong Med Univ Dept Pharmacol Zhanjiang 524023 Peoples R China;

Guangdong Med Univ Marine Biomed Res Inst 2 Wenming Dong Rd Zhanjiang 524023 Guangdong Peoples;

Guangdong Med Univ Marine Biomed Res Inst 2 Wenming Dong Rd Zhanjiang 524023 Guangdong Peoples;

Guangdong Med Univ Marine Biomed Res Inst 2 Wenming Dong Rd Zhanjiang 524023 Guangdong Peoples;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Astaxanthin; miR-31-5p; Numb; Notch; M1 activation;

机译：虾青素;miR-31-5p;麻木的缺口M1激活;

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1. Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis [J] . Yu-Liang Zhao, Ling Zhang, Ying-Ying Yang, 中华医学杂志（英文版） . 2016,第009期
2. Berberine inhibits inflammatory activation of rat brain microglia [J] . Kyong Nyon Nam, Jae-Hong Kim, Hoon-Ji Jung, 中国神经再生研究（英文版） . 2010,第018期
3. Berberine inhibits inflammatory activation of rat brain microglia [J] . Kyong Nyon Nam, Jae-Hong Kim, Hoon-Ji Jung, 中国神经再生研究：英文版 . 2010,第018期
4. Dexmedetomidine reduces hippocampal microglia inflammatory response induced by surgical injury through inhibiting NLRP3 [J] . Ji Peng, Peng Zhang, Han Zheng, 中华创伤杂志（英文版） . 2019,第003期
5. PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model [J] . Xilei Li, Qulian Guo, Zhi Ye, Frontiers in Neuropharmacology . 2021,第a期

机译：PPARγ通过坐标慢性收缩损伤模型通过下调节CX3CR1并通过曲线慢性收缩损伤模型衰减大鼠脊髓中微胶质细胞的M1活化的神经疗法
6. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a [J] . Jiang Rui, Hao Peng, Yu Guisheng, International immunopharmacology . 2019,第期

机译：Kaempferol通过下调miR-146a来保护脂多糖引发的炎症损伤的炎症损伤。
7. Caldecrin inhibits lipopolysaccharide-induced pro-inflammatory cytokines and M1 macrophage polarization through the immunoreceptor triggering receptor expressed in myeloid cells-2 [J] . Bandow Kenjiro, Hasegawa Hiroya, Tomomura Mineko, Biochemical and Biophysical Research Communications . 2020,第4期

机译：Caldecrin通过骨髓细胞-2中表达的免疫受体触发受体抑制脂多糖诱导的促炎细胞因子和M1巨噬细胞极化
8. GITR-FC Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response Following Spinal Cord Injury [C] . T. Genovese, G. Nocentini, S. Cuzzocrea, Conference on Shock . 2008

机译：GITR-FC融合蛋白抑制GITR触发并保护脊髓损伤后炎症反应免受炎症反应
9. Antipsychotic Compounds Inhibit Inflammatory Stimulation of TNFα from Microglia: Relevance to Hemorrhagic Stroke, Alzheimer’s Disease and Other Inflammatory Diseases [D] . Vicari, James Michael 2019

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10. PPAR γ Prevents Neuropathic Pain by Down-Regulating CX3CR1 and Attenuating M1 Activation of Microglia in the Spinal Cord of Rats Using a Sciatic Chronic Constriction Injury Model [O] . Xilei Li, Qulian Guo, Zhi Ye, 2021

机译：PPARγ通过坐标慢性收缩损伤模型降低CX3CR1并通过序曲慢性收缩损伤模型衰减大鼠脊髓中微胶质细胞的M1活化
11. Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury [O] . Bohui Li, Chunmei Liu, Kaihong Tang, 2019

机译：Aquaporin-1通过抑制P38丝裂原激活的蛋白激酶活化在脂多糖诱导的急性肾损伤中衰减巨噬细胞介导的炎症反应
12. Comparison of 2 Luminex-based Multiplexed Protein Assays for Quantifying Microglia Activation and Inflammatory Proteins. [R] . Campbell, L., Wires, E., Harvey, B., 2016

机译：基于2 Luminex的多重蛋白质分析用于量化小胶质细胞活化和炎性蛋白质的比较。

Astaxanthin inhibits microglia M1 activation against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-31-5p

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