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首页> 外文期刊>LWT-Food Science & Technology >Antioxidant and anti-norovirus properties of aqueous acetic acid macromolecular extracts of edible brown macroalgae
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Antioxidant and anti-norovirus properties of aqueous acetic acid macromolecular extracts of edible brown macroalgae

机译：食用棕色大型乙酸水溶液水溶液的抗氧化剂和抗诺维病毒性质

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摘要

Previous studies reported the activity of fucoidans and polyphenols (phlorotannins) extracted from brown algae against enveloped viruses. The aim of this study was to investigate the effects of brown macroalgae on the non-enveloped norovirus. Aqueous acetic acid macromolecular (>3 kDa) extracts (AAEs) were obtained from ten samples of eight brown macroalgal species. Saccharides and sulphate composition, weight-averaged molecular weight, and total phenolic content (TPC) of the AAEs were measured to estimate their fucoidan and polyphenol content. Murine RAW264.7 macrophage cells and the human norovirus surrogate murine norovirus-1 (MNV-1) were used for the anti-norovirus assay. One hour of direct exposure to TPC-rich AAEs from Sargassum horneri (Sh), Eisenia bicyclis (Eb), Cladosiphon okamuranus (Co), and Undaria pinnatifida inactivated MNV-1. In contrast, pre-treatment of RAW264.7 cells for 20 h with AAEs from another U. pinnatifida sample, Analipus japonicus, and Co protected RAW264.7 cells against MNV-1 infection. The AAEs from Co contained high TPC and sulphated fucans (fucoidans) might be the most promising anti-norovirus agents as they directly inactivated MNV-1 and protected RAW264.7 cells from it. The AAEs of phlorotannin-rich Sh and Eb are also potentially effective at direct inactivating MNV-1.
机译：以前的研究报告了褐藻中提取的岩藻糖胶和多酚（间苯三酚）对抗包膜病毒的活性。本研究的目的是研究褐藻对无包膜诺沃克病毒的影响。从8种褐藻的10个样品中获得了水乙酸大分子（>3kDa）提取物（AAE）。测定AAE的糖和硫酸盐组成、重均分子量和总酚含量（TPC），以估计其褐藻糖胶和多酚含量。小鼠RAW264。使用7个巨噬细胞和人诺沃克病毒替代物小鼠诺沃克病毒-1（MNV-1）进行抗诺沃克病毒试验。一小时直接暴露于富含TPC的AAE，AAE来自马尾藻（Sh）、双环艾森氏菌（Eb）、冈山枝孢菌（Co）和裙带菜灭活MNV-1。相比之下，RAW264的预处理。7个细胞培养20小时，使用另一种美国羽状亚种样本日本亚种的AAEs和共同保护的RAW264。7个抗MNV-1感染的细胞。来自Co的AAE含有高TPC和硫酸岩藻聚糖（岩藻多糖），可能是最有前途的抗诺如病毒药物，因为它们直接灭活MNV-1并保护RAW264。7个细胞。富含间苯三酚的Sh和Eb的AAE也可能对直接灭活MNV-1有效。

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