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首页> 外文期刊>Optics Letters >Spectral interferometric depth-resolved photoacoustic viscoelasticity imaging
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Spectral interferometric depth-resolved photoacoustic viscoelasticity imaging

机译:光谱干涉深度分辨光声粘弹性成像

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摘要

Viscoelasticity is closely related to the physiological characteristics of biological tissues. In this Letter, we propose a novel spectral interferometric depth-resolved photoacoustic viscoelasticity imaging (SID-PAVEI) method, to the best of our knowledge for the first time, which breaks the plight of surface viscoelasticity imaging and achieves an internal visible microscale SID-PAVEI in a noncontact fashion. In this work, we employ a high-sensitive and depth-resolved spectral domain low coherence interferometry (SDLCI) to remotely track photoacoustic-induced strain response of absorbers in situ. By decoupling the phase and amplitude of the photoacoustic-encoded spectral interference signal, the SID-PAVEI and scattering structure imaging (SSI) can be obtained simultaneously. Depth-resolved performance of the SID-PAVEI and the SSI in one scan were demonstrated by imaging biological tissues. The method opens new perspectives for three-dimensional microscale viscoelasticity imaging and provides a great potential in multi-parametric characterizing pathological information. (C) 2021 Optical Society of America.
机译:粘弹性与生物组织的生理特性密切相关。在这封信中,我们首次提出了一种新的光谱干涉深度分辨光声粘弹性成像(SID-PAWI)方法,打破了表面粘弹性成像的困境,以非接触方式实现了内部可见微尺度SID-PAWI。在这项工作中,我们采用了一种高灵敏度和深度分辨的光谱域低相干干涉术(SDLCI)来远程跟踪吸收体在原位的光声诱导应变响应。通过对光声编码光谱干涉信号的相位和振幅进行解耦,可以同时获得SID-PAVI和散射结构成像(SSI)。通过生物组织成像,证明了SID-PAVEI和SSI在一次扫描中的深度分辨性能。该方法为三维微尺度粘弹性成像开辟了新的前景,在多参数表征病理信息方面具有巨大潜力。(2021)美国光学学会。

著录项

  • 来源
    《Optics Letters》 |2021年第7期|共4页
  • 作者单位

    South China Normal Univ Coll Biophoton MOE Key Lab Laser Life Sci Guangzhou 510631 Peoples R China;

    Fujian Med Univ Sch Med Technol &

    Engn Dept Ophthalmol &

    Optometry Fuzhou 350004 Peoples R China;

    South China Normal Univ Coll Biophoton MOE Key Lab Laser Life Sci Guangzhou 510631 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 计量学;光学;
  • 关键词

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