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首页> 外文期刊>Separation and Purification Technology >Development of separation method for Alpha-Tocopherol and Gamma-Oryzanol extracted from rice bran oil using Three-Zone simulated moving bed process
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Development of separation method for Alpha-Tocopherol and Gamma-Oryzanol extracted from rice bran oil using Three-Zone simulated moving bed process

机译：用三区模拟移动床工艺从稻糠油中提取α-生育酚和γ-葡聚糖的分离方法

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摘要

Gamma-oryzanol and alpha-tocopherol are bio-active compounds that can be found in crude extract of rice bran oil. With superior properties of gamma-oryzanol such as antioxidant activities, anticancer, and antidiabetic, while alpha-tocopherol is one type of vitamin-E, they are both widely used in foods, pharmaceuticals, nutraceuticals, and cosmetic. Therefore, the isolation of these compounds from the crude extract to obtain a single component with high purity is important. In this study, the separation of gamma-oryzanol and alpha-tocopherol using chromatographic method was investigated. The type of mobile phase for C18 column was selected based on the selectivity, back pressure, and toxicity. The adsorption of mono-component was performed to determine the adsorption parameters and the mathematical model for breakthrough curves was developed. The model and the associated parameters were validated by the adsorption experiments using binary mixture. The verified model was used in the design and optimization of three-zone simulated moving bed process. The mobile phase was the mixture of ethanol and water (90 :10 V/V%). At the optimal conditions of the three-zone simulated moving bed, the purity of extract product (rich in gamma-oryzanol), the purity of raffinate product (rich in alpha-tocopherol), and the separation productivity were 99.24%, 98.69% and 29.87 g/L.min, respectively.
机译：γ-谷维素和α-生育酚是米糠油粗提取物中的生物活性化合物。γ-谷维素具有抗氧化、抗癌和抗糖尿病等优良性质，而α-生育酚是维生素E的一种，它们都广泛用于食品、药品、保健品和化妆品中。因此，从粗提物中分离这些化合物以获得高纯度的单一组分非常重要。本研究采用色谱法对γ-谷维素和α-生育酚的分离进行了研究。根据选择性、背压和毒性选择C18柱的流动相类型。通过对单组分的吸附来确定吸附参数，并建立了穿透曲线的数学模型。通过二元混合物吸附实验验证了模型和相关参数。将验证后的模型用于三区模拟移动床工艺的设计和优化。流动相为乙醇和水的混合物（90:10v/V%）。在三区模拟移动床的最佳条件下，萃取产物的纯度（富含γ-谷维素）、萃余产物的纯度（富含α-生育酚）和分离效率分别为99.24%、98.69%和29.87 g/L.min。

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