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首页> 外文期刊>Surgical Endoscopy >Laparoscopic gastrectomy and metastasectomy for stage IV gastric cancer
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Laparoscopic gastrectomy and metastasectomy for stage IV gastric cancer

机译：腹腔镜胃切除术和阶段IV胃癌切除术

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摘要

Background The standard recommended treatment of stage IV gastric cancer is palliative chemotherapy. The aim of this study is to evaluate the role of radical gastrectomy with metastasectomy in these patients, as well as to explore the feasibility and safety of a laparoscopic approach. Methods 117 consecutive patients with pathologically proven Stage IV gastric cancer who underwent radical gastrectomy with metastasectomy were enrolled in this study. We evaluated short-term and long-term outcomes, comparing laparoscopic surgery with open surgery by propensity score matching. Results The 5-year overall survival rate (OSR) was 23.2% and the median survival time (MST) was 19.8 months. After propensity scoring matching, the 5-year OSR and MST of laparoscopy group was 23.4%, 17.9 months and in the open group, it was 25.0%, 22.8 months (p = 0.882). The complication rate was 5.6% in the laparoscopy group and 23.4% in the open group (p = 0.069). In multivariate analysis, adjuvant chemotherapy, chemotherapy cycle, and postoperative complication were independent prognostic factors of overall survival. Conclusions Radical gastrectomy with metastasectomy could have a potential role in stage IV gastric cancer. Laparoscopic gastrectomy with metastasectomy in selected stage IV gastric cancer patients is safe and feasible.
机译：背景IV期胃癌的标准推荐治疗方法是姑息性化疗。本研究的目的是评估根治性胃切除术和转移瘤切除术在这些患者中的作用，以及探讨腹腔镜手术的可行性和安全性。方法117例经病理证实的Ⅳ期胃癌患者接受了根治性胃切除术并转移性切除术。我们通过倾向评分匹配比较腹腔镜手术和开腹手术，评估短期和长期结果。结果5年总生存率（OSR）为23.2%，中位生存时间（MST）为19.8个月。倾向评分匹配后，腹腔镜组的5年OSR和MST分别为23.4%和17.9个月，开放组分别为25.0%和22.8个月（p=0.882）。腹腔镜组并发症发生率为5.6%，开放组为23.4%（p=0.069）。在多变量分析中，辅助化疗、化疗周期和术后并发症是总生存率的独立预后因素。结论根治性胃切除术伴转移性切除术可能在IV期胃癌中发挥潜在作用。腹腔镜胃切除术伴转移性切除术在部分IV期胃癌患者中是安全可行的。

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  • 来源
    《Surgical Endoscopy》 |2021年第4期|共9页
  • 作者

    Min Sa-Hong; Won Yongjoon; Lee Kanghaeng; Youn Sang Il; Kim Guowei; Park Young Suk; Ahn Sang-Hoon; Park Joong Do; Kim Hyung-Ho;

  • 作者单位

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

    Seoul Natl Univ Dept Surg Bundang Hosp 82 Gumi Ro 173 Beon Gil Seongnam Si 13620 Gyeonggi Do;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Laparoscopy; Advanced gastric cancer; Gastrectomy; Metastasis; Survival;

    机译：腹腔镜;进展期胃癌;胃切除术;转移;生存;

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