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首页> 外文期刊>Surgical Endoscopy >Comparison of minimal invasive versus open radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic ductal adenocarcinoma: a single center retrospective study
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Comparison of minimal invasive versus open radical antegrade modular pancreatosplenectomy (RAMPS) for pancreatic ductal adenocarcinoma: a single center retrospective study

机译：胰腺导管腺癌的最小侵入性与开放式切除模块化胰腺渗透术（斜坡）的比较：单一中心回顾性研究

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摘要

Introduction Radical antegrade modular pancreatosplenectomy (RAMPS) was proposed a decade ago with the aim to achieve higher R0 tangential margin and radical N1 lymph node resection for left-sided pancreatic adenocarcinoma (PDAC), which has been widely accepted worldwide at present. Laparoscopic RAMPS (Lap-RAMPS) has been attempted for PDAC during last several years, however, no outcomes evaluation by comparison between laparoscopic vs open RAMPS has been reported yet. Materials and methods From August, 2012 to March, 2018, patients undergoing open or lap-RAMPS for the diagnosis of left-sided PDAC were reviewed from a prospective database. Patients excluded if they were related with combined organs or vessels resection, systematic metastasis as well as conversion from open RAMPS to lap RAMPS. The surgical and oncologic outcomes were compared. Results A total of 48 PDAC patients were enrolled (25 underwent lap-RAMPS and 23 underwent open-RAMPS). There were no significant differences in demographic or perioperative morbidity. In the lap-RAMPS group, R0 transection margin and retroperitoneal margin were both achieved in 23 of 25 patients (92%). In the open RAMPS group, R0 transection margin was achieved in 21 of 23 patients (91.3%), R0 retroperitoneal margin was 22 of 23 patients (95.65%). There were no differences in pathological examinations. The number of lymph node (LN) retrieved between lap-RAMPS and open- RAMPS group was not significant difference (15.84 vs 18.22;P = 0.268). Median disease-free survival (DFS) was analogous in two groups (18.11 m vs 20.00 m,P = 0.999). Median overall survival (OS) was 24.53 m in lap-RAMPS group and 28.73 m in the open-RAMPS group (P = 0.633). Conclusions Lap-RAMPS is technically feasible, and has comparable long-term oncological outcome with open-RMAPS.
机译：导言根治性顺行模块化胰脊髓切除术（RAMPS）是十年前提出的，目的是为左侧胰腺癌（PDAC）实现更高的R0切缘和根治性N1淋巴结切除，目前已在世界范围内被广泛接受。在过去几年中，有人尝试使用腹腔镜斜坡（Lap-RAMPS）治疗PDAC，然而，还没有通过比较腹腔镜斜坡和开放式斜坡的结果进行评估的报道。材料和方法从2012年8月至2018年3月，从前瞻性数据库中回顾了因左侧PDAC诊断而接受开放式或重叠式斜坡手术的患者。如果患者与联合器官或血管切除、系统性转移以及从开放性斜坡到lap斜坡的转换有关，则排除在外。比较手术和肿瘤学结果。结果共纳入48例PDAC患者（25例接受lap坡道，23例接受开放坡道）。人口统计学和围手术期发病率没有显著差异。在lap-RAMPS组，25例患者中有23例（92%）达到R0横断边缘和腹膜后边缘。在开放性斜坡组，23例患者中有21例（91.3%）达到R0横断边缘，23例患者中有22例（95.65%）达到R0腹膜后边缘。病理检查无差异。lap斜坡组和开放斜坡组的淋巴结（LN）取回数无显著差异（15.84对18.22；P=0.268）。两组的中位无病生存率（DFS）相似（18.11 m vs 20.00 m，P=0.999）。中位总生存率（OS）在膝上坡道组为24.53米，开放坡道组为28.73米（P=0.633）。结论Lap-RAMPS在技术上是可行的，并且与开放式RMAP具有可比的长期肿瘤学结果。

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  • 来源
    《Surgical Endoscopy》 |2021年第7期|共11页
  • 作者

    Zhang Hanyu; Li Yatong; Liao Quan; Xing Cheng; Ding Cheng; Zhang Taiping; Guo Junchao; Han Xianlin; Xu Qiang; Wu Wenming; Zhao Yupei; Dai Menghua;

  • 作者单位

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

    Peking Union Med Coll &

    Chinese Acad Med Sci Peking Union Med Coll Hosp Dept Gen Surg 1 Shuai Fu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Pancreatic cancer; Minimal invasive surgery; Radical antegrade modular pancreatosplenectomy; RAMPS; Laparoscopic distal pancreatectomy;

    机译：胰腺癌;微创手术;根治性顺行模块化胰脊髓切除术;坡道;腹腔镜下远端胰腺切除术;

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