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首页> 外文期刊>Surgical Endoscopy >Short- and long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell cancer in patients with prior gastrectomy
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Short- and long-term outcomes of endoscopic submucosal dissection for superficial esophageal squamous cell cancer in patients with prior gastrectomy

机译：患有现有胃切除术患者的浅表性食管鳞状细胞癌的内窥镜粘膜缺陷的短期和长期结果

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摘要

Background The surgery for esophageal cancer arising after prior gastrectomy is technically difficult with high morbidity and mortality. Endoscopic submucosal dissection (ESD) is a minimally invasive endoscopic treatment for superficial SCC with high curative resection rate. But few studies are concerned about ESD under these circumstances. The aim of this study was to elucidate the short- and long-term outcomes of ESD for superficial esophageal squamous cell cancer (SCC) in patients with prior gastrectomy. Methods From January 2009 to January 2019, 37 patients with prior gastrectomy who underwent ESD for superficial esophageal SCC were retrospectively enrolled at the Zhongshan Hospital, Fudan University in Shanghai, China. Rates of en bloc resection, complete resection, curative resection, incidence of postoperative bleeding, perforation and postoperative stricture were evaluated as short-term outcomes. Overall survival, and local recurrence-free survival were evaluated as long-term outcomes. Results The rate of en bloc resection, complete resection and curative resection were 94.6%, 86.5% and 78.4%, respectively. No perforation was observed. 1 (2.7%) patient experienced postoperative bleeding. During the median observation of 43 months, 3 (8.6%) patients experienced esophageal stricture, successfully managed by balloon dilation. 3(8.6%) patients had local recurrence after ESD with 5-year local recurrence-free survival rate of 91.4%. During the observation period, 4 patients died of other reasons. The 1, 3, 5-year overall survival rates were 97.1%, 97.1% and 91.4%. Conclusions The short-term outcomes indicate ESD is technically difficult with lower resection completeness in patients after gastrectomy, while the long-term outcomes are rather favorable.
机译：背景胃切除术后食管癌的手术技术难度大，发病率和死亡率高。内镜黏膜下剥离术（ESD）是一种微创内镜治疗浅表鳞状细胞癌的方法，切除率高。但在这种情况下，很少有研究关注ESD。本研究的目的是阐明ESD治疗胃切除术后浅表食管鳞状细胞癌（SCC）的短期和长期疗效。方法从2009年1月至2019年1月，中国上海复旦大学中山医院回顾性登记了37例因浅表食管鳞状细胞癌行ESD胃切除术的患者。短期结果评估整体切除率、完全切除率、治愈性切除率、术后出血、穿孔和术后狭窄的发生率。总生存率和无局部复发生存率被评估为长期结果。结果整体切除率为94.6%，完全切除率为86.5%，根治性切除率为78.4%。未观察到穿孔。术后出血1例（2.7%）。在43个月的中位观察期间，3例（8.6%）患者出现食管狭窄，通过球囊扩张成功治疗。ESD术后局部复发3例（8.6%），5年无局部复发生存率91.4%。在观察期间，4名患者因其他原因死亡。1年、3年、5年总生存率分别为97.1%、97.1%和91.4%。结论胃切除术后患者的短期结果表明ESD在技术上是困难的，切除完整性较低，而长期结果是相当有利的。

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  • 来源
    《Surgical Endoscopy》 |2021年第5期|共11页
  • 作者

    Xu Jia-Qi; Hu Jian-Wei; Chen Wei-Feng; Xu Mei-Dong; Zhong Yun-Shi; Chen Shi-Yao; Zhang Yi-Qun; Ma Li-Li; Qin Wen-Zheng; Cai Ming-Yan; Yao Li-Qing; Zhou Ping-Hong; Li Quan-Lin;

  • 作者单位

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

    Fudan Univ Zhongshan Hosp Endoscopy Ctr 180 FengLin Rd Shanghai 200032 Peoples R China;

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  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Endoscopic submucosal dissection; Superficial esophageal squamous cell cancer; Prior gastrectomy;

    机译：内镜黏膜下剥离术;浅表性食管鳞状细胞癌;胃切除术前;

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