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首页> 外文期刊>Surgical Endoscopy >Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model
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Intragastric satiety-inducing device reduces food intake and suppresses body weight gain in a rodent model

机译：胃内饱腹感引起的装置可减少食物摄入并抑制啮齿动物模型中的体重增加

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摘要

Background An intragastric satiety-inducing device (ISD) (Full Sense Device; Baker, Foote, Kemmeter, Walburn, LLC, Grand Rapids, MI) is a novel weight-loss device, which may induce satiety by applying continuous pressure on the gastric cardia. This study investigated the effect of the ISD on food intake and body weight gain in a rodent model. Methods Thirty-two male Sprague-Dawley rats (weight, 250-300 g) were randomly divided into four groups of eight individuals. Single-disk (SD) and double-disk (DD) group animals underwent peroral placement of a single- or double-disk ISD, respectively, under fluoroscopic guidance. The ISD comprised a 4 mm x 1.5 cm nitinol stent placed in the lower esophagus and one (single-disk) or two (double-disk) 2.5-cm-diameter star-shaped nitinol disks placed in the gastric fundus. Esophageal stent (ES) and sham-operated (SO) group animals underwent peroral placement of the ES part of the ISD and a sham operation, respectively. Results Food intake was significantly different among the four groups over the 4-week study period (P 0.999) and between the ES and SO groups (P = 0.677). Body weight was significantly different among the four groups by the end of the study period (P < 0.001); body weight was significantly lower in the DD group than in the SD, ES, and SO groups (P = 0.010, P < 0.001, and P < 0.001, respectively) and in the SD group than in the SO group (P = 0.001), but it was not significantly different between the ES and SO groups (P = 0.344). Conclusion ISD reduced food intake and suppressed body weight gain in a rodent model.
机译：背景胃内饱腹感诱导装置（ISD）（全感官装置；贝克、富特、肯米特、沃尔伯恩、LLC、密歇根州大急流城）是一种新型减肥装置，可通过对贲门施加持续压力来诱导饱腹感。本研究在啮齿类动物模型中研究了ISD对食物摄入和体重增加的影响。方法32只雄性Sprague-Dawley大鼠（体重250-300g）随机分为4组，每组8只。单椎间盘（SD）和双椎间盘（DD）组动物分别在荧光镜指导下经口放置单椎间盘或双椎间盘ISD。ISD包括一个4 mm x 1.5 cm的镍钛合金支架放置在食管下部，以及一个（单盘）或两个（双盘）直径2.5 cm的星形镍钛合金盘放置在胃底。食管支架（ES）和假手术（SO）组动物分别经口放置ISD的ES部分和假手术。结果在为期4周的研究期间，四组之间的食物摄入量存在显著差异（P0.999），ES组和SO组之间的食物摄入量存在显著差异（P=0.677）。研究结束时，四组之间的体重差异显著（P<0.001）；DD组的体重显著低于SD、ES和SO组（分别为P=0.010、P<0.001和P<0.001），SD组的体重显著低于SO组（P=0.001），但ES组和SO组之间的体重差异不显著（P=0.344）。结论ISD可减少啮齿动物模型的摄食量，抑制体重增加。

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  • 来源
    《Surgical Endoscopy》 |2021年第3期|共6页
  • 作者

    Luo Yingen; Zhang Xiaowu; Tsauo Jiaywei; Jung Hwoon-Yong; Song Ho-Young; Zhao He; Li Jingui; Gong Tao; Song Peng; Li Xiao;

  • 作者单位

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Univ Ulsan Dept Gastroenterol Asan Med Ctr Coll Med Seoul 05505 South Korea;

    Univ Ulsan Dept Radiol Asan Med Ctr Coll Med Seoul 138736 South Korea;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

    Chinese Acad Med Sci Dept Intervent Therapy Natl Canc Ctr Natl Clin Res Ctr Canc Canc Hosp 17;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Bariatric medicine; Bariatrics; Obesity; Obesity management; Weight loss; Self-expandable metallic stents;

    机译：减肥药;减肥医生;肥胖肥胖管理;减肥;自膨胀金属支架;

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