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首页> 外文期刊>Surgical Endoscopy >Comprehensive Analysis of Adverse Events Associated with Gastric Peroral Endoscopic Myotomy: An International Multicenter Study
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Comprehensive Analysis of Adverse Events Associated with Gastric Peroral Endoscopic Myotomy: An International Multicenter Study

机译：胃肠内镜术治疗术的不良事件综合分析：国际多中心研究

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摘要

Background Gastric peroral endoscopic myotomy (G-POEM) has emerged as an effective management approach for patients with refractory gastroparesis. This study aims to comprehensively study the safety of G-POEM and describe the predictive factors of adverse events (AEs) occurrence. Methods This study is a retrospective study involving 13 tertiary care centers (7 USA, 1 South America, 4 Europe, and 1 Asia). Patients who underwent G-POEM for refractory gastroparesis were included. Cases were identified by the occurrence of AEs. For each case, two controls were randomly selected and matched for age (+/- 10 years), gender, and etiology of gastroparesis. Results A total of 216 patients underwent G-POEM for gastroparesis. Overall, 31 (14%) AEs were encountered [mild 24 (77%), moderate 5 (16%), and severe 2 (6%)] during the duration of the study. The most common AE was abdominal pain (n = 16), followed by mucosotomy (n = 5) and capnoperitoneum (n = 4), and AEs were most commonly identified within the first 48-h post-procedure 18 (58%). The risk of adverse event occurrence was significantly higher for endoscopists with experience of 20 G-POEM procedures is significantly associated with decreased incidence of AEs.
机译：背景胃经口内镜肌切开术（G-POEM）已成为难治性胃轻瘫患者的有效治疗方法。本研究旨在全面研究G-POEM的安全性，并描述不良事件（AEs）发生的预测因素。方法本研究是一项回顾性研究，涉及13个三级护理中心（7个美国、1个南美、4个欧洲和1个亚洲）。包括因难治性胃轻瘫而接受G-POY治疗的患者。通过不良事件的发生来确定病例。对于每个病例，随机选择两个对照组，并根据年龄（+/-10岁）、性别和胃轻瘫病因进行匹配。结果216例胃轻瘫患者接受G-POEM检查。总体而言，在研究期间共发生31例（14%）不良事件[轻度24例（77%）、中度5例（16%）和重度2例（6%）。最常见的不良事件是腹痛（n=16），其次是粘液切开术（n=5）和腹膜囊切开术（n=4），最常见的不良事件发生在术后48小时内18例（58%）。有20次G-POEM手术经验的内窥镜师发生不良事件的风险显著较高，这与不良事件发生率的降低显著相关。

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  • 来源
    《Surgical Endoscopy》 |2021年第4期|共10页
  • 作者

    Ichkhanian Y.; Vosoughi K.; Meybodi M. Aghaie; Jacques J.; Sethi A.; Patel A. A.; Aadam A. A.; Triggs J. R.; Bapaye A.; Dorwat S.; Benias P.; Chaves D. M.; Barret M.; Law R. J.; Browers N.; Pioche M.; Draganov P. V; Kotzev A.; Estremera F.; Albeniz E.; Ujiki M. B.; Callahan Z. M.; Itani I. M.; Brewer O. G.; Khashab M. A.;

  • 作者单位

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

    Limoges Univ Hosp Gastroenterol Dept 2 Ave Martin Luther King F-87042 Rouen France;

    Columbia Univ Div Digest &

    Liver Dis Med Ctr New York NY USA;

    Columbia Univ Div Digest &

    Liver Dis Med Ctr New York NY USA;

    Northwestern Univ Feinberg Sch Med Div Gastroenterol &

    Hepatol Chicago IL 60611 USA;

    Northwestern Univ Feinberg Sch Med Div Gastroenterol &

    Hepatol Chicago IL 60611 USA;

    Deenanath Mangeshkar Hosp &

    Res Ctr Dept Digest Dis &

    Endoscopy Pune Maharashtra India;

    Deenanath Mangeshkar Hosp &

    Res Ctr Dept Digest Dis &

    Endoscopy Pune Maharashtra India;

    Long Isl Jewish Med Ctr Div Gastroenterol Zucker Sch Med Hofstra Northwell Northwell Hlth Syst;

    Univ Sao Paulo Hosp Clin HCFMUSP Fac Med Gastroenterol Sao Paulo SP Brazil;

    Univ Paris 05 Cochin Univ Hosp Gastroenterol Unit Paris France;

    Univ Michigan Hlth Care Syst Ann Arbor MI USA;

    Univ Michigan Hlth Care Syst Ann Arbor MI USA;

    CHU Lyon Serv Hepatogastroenterol Hop Edouard Herriot Lyon France;

    Univ Florida Div Gastroenterol Hepatol &

    Nutr Gainesville FL USA;

    Univ Hosp Alexandrovska Clin Gastroenterol Sofia Bulgaria;

    Univ Hosp Alexandrovska Clin Gastroenterol Sofia Bulgaria;

    Complejo Hosp Navarra Div Gastroenterol Pamplona Spain;

    NorthShore Univ Hlth Syst Dept Surg Sect Minimally Invas Surg Evanston IL USA;

    NorthShore Univ Hlth Syst Dept Surg Sect Minimally Invas Surg Evanston IL USA;

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

    Johns Hopkins Med Inst Div Gastroenterol &

    Hepatol Baltimore MD 21205 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Gastric peroral endoscopic myotomy; G-POEM; Adverse events; Gastroparesis;

    机译：胃经口内镜下肌切开术;G-诗;不良事件;胃轻瘫;

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