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首页> 外文期刊>Surgical Endoscopy >Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study
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Naples Prognostic Score as a novel prognostic prediction tool in video-assisted thoracoscopic surgery for early-stage lung cancer: a propensity score matching study

机译：那不勒斯预后得分作为一种新型预后预测工具，用于早期肺癌的视频辅助胸腔镜手术：倾向得分匹配研究

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摘要

Backgrounds The Naples Prognostic Score (NPS) emerges as a novel prognostic scoring system in surgical oncology. We aim to assess the prognostic significance of preoperative NPS in patients undergoing completely video-assisted thoracoscopic surgery (VATS) lobectomy for early-stage non-small cell lung cancer (NSCLC) by propensity score matching (PSM) analysis. Methods The present study was conducted on our single-center prospectively maintained database between January 2014 and December 2015. A Kaplan-Meier survival analysis using the log-rank test was used to distinguish differences in both overall survival (OS) and disease-free survival (DFS) between the patients stratified by preoperative NPS. Finally, multivariable Cox-proportional hazards regression analysis and PSM analysis were carried out to determine the independent prognostic factors for both OS and DFS. Results There were 457 patients with operable primary stage I-II NSCLC included. Per 1-point increase in NPS was found to be significantly associated with unfavorable OS and DFS of NSCLC. Both OS and DFS were significantly shortened along with each number increase in the NPS group, showing a step-wise fashion. Such strong correlations between preoperative NPS and survival outcomes still remained validated after PSM analysis. In addition, NPS held the best discriminatory power for predicting both OS and DFS when compared to the other peripheral biomarkers. Multivariable analyses on the entire cohort and the PSM cohort demonstrated that preoperative NPS could be an independent prognostic indicator for both OS and DFS. Conclusions The NPS scoring system can serve as a novel risk stratification tool to refine prognostic prediction after VATS lobectomy for surgically resected NSCLC.
机译：背景那不勒斯预后评分（NPS）作为一种新的肿瘤外科预后评分系统应运而生。我们的目的是通过倾向评分匹配（PSM）分析评估早期非小细胞肺癌（NSCLC）患者接受完全电视辅助胸腔镜手术（VATS）肺叶切除术前NPS的预后意义。方法本研究于2014年1月至2015年12月在我们的单中心前瞻性维护数据库上进行。采用对数秩检验进行Kaplan-Meier生存分析，以区分按术前NPS分层的患者之间总生存率（OS）和无病生存率（DFS）的差异。最后，进行多变量Cox比例风险回归分析和PSM分析，以确定OS和DFS的独立预后因素。结果包括457例可手术的原发性I-II期非小细胞肺癌。每增加1个百分点的NPS被发现与NSCLC的不良OS和DFS显著相关。NPS组的OS和DFS均随着每个数字的增加而显著缩短，呈现出逐步缩短的趋势。在PSM分析后，术前NPS和生存结果之间的这种强相关性仍然得到验证。此外，与其他外周生物标志物相比，NPS在预测OS和DFS方面具有最佳的鉴别能力。对整个队列和PSM队列的多变量分析表明，术前NPS可能是OS和DFS的独立预后指标。结论NPS评分系统可作为一种新的风险分层工具，用于改善非小细胞肺癌手术切除的VATS肺叶切除术后的预后预测。

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  • 来源
    《Surgical Endoscopy》 |2021年第7期|共19页
  • 作者

    Li Shuangjiang; Wang Hongyu; Yang Zhang; Zhao Liang; Lv Wenyu; Du Heng; Che Guowei; Liu Lunxu;

  • 作者单位

    Sichuan Univ West China Hosp Dept Thorac Surg Chengdu 610041 Peoples R China;

    Hubei Univ Med Affiliated Dongfeng Hosp Dept Thorac &

    Cardiovasc Surg Shiyan 442008 Peoples R;

    Univ Bern Bern Univ Hosp Div Gen Thorac Surg Inselspital CH-3010 Bern Switzerland;

    Univ Bern Bern Univ Hosp Div Gen Thorac Surg Inselspital CH-3010 Bern Switzerland;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Cardiol Guangzhou 510120 Peoples R China;

    Harvard Med Sch Brigham &

    Womens Hosp Div Pulm Med Boston MA 02115 USA;

    Sichuan Univ West China Hosp Dept Thorac Surg Chengdu 610041 Peoples R China;

    Sichuan Univ West China Hosp Dept Thorac Surg Chengdu 610041 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 诊断学;
  • 关键词

    Naples prognostic score; Non-small cell lung cancer; Video-assisted thoracoscopic surgery;

    机译：那不勒斯预后评分;非小细胞肺癌;电视胸腔镜手术;

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