...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Surgical Endoscopy >A validated score predicting common bile duct stone in patients hospitalized with acute calculus cholecystitis: a multi-center retrospective study
【24h】

A validated score predicting common bile duct stone in patients hospitalized with acute calculus cholecystitis: a multi-center retrospective study

机译：验证得分预测急性微观胆囊炎住院患者的常见胆管石：多中心回顾性研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Concomitant common bile duct (CBD) stone in the setting of acute calculous cholecystitis (ACC) should be suspected once abnormal liver indices are noticed. Aim We aimed to identify predictors of CBD stone in patients hospitalized with ACC. Methods We performed a retrospective multi-center, case-controlled, study from 1st of January 2016 until the 31th of December 2018. Inclusion criteria included patients with an established diagnosis of ACC based on clinical, laboratory and radiological criteria and who had an endoscopic ultrasound (EUS) for suspected CBD stone. One-hundred and twelve patients were included, of these fifty-three patients (47.3%) were diagnosed with CBD stone by EUS. Results In univariate analysis, Age(OR 1.038,P = 0.001), total bilirubin (mg/dl) (OR 1.429,P = 0.02) and CBD width (mm) by US (OR 1.314,P = 0.01) were statistically significant in predicting CBD stone and remained significant in multivariate regression analysis. We developed a diagnostic score that included these three parameters, with assignment of weights for each variable according to the coefficient estimate. A low cut-off score of 0 was associated with sensitivity of 100% for CBD stone, whereas a high cut-off score of 3 was associated with sensitivity of 10% and specificity of 96.6% with a positive predictive value of 67% (ROC of 0.7558). We validated this score with an independent cohort (ROC of 0.7416) with a sensitivity of 46.6%, a specificity of 91.5% and a PPV of 87.1%. Conclusion We recommend incorporating this score as an aid for stratifying patients with ACC into low or high probability for concomitant CBD stone.
机译：背景：一旦发现肝脏指标异常，应怀疑急性结石性胆囊炎（ACC）合并胆总管（CBD）结石。目的我们旨在确定ACC住院患者中CBD结石的预测因素。方法我们从2016年1月1日至2018年12月31日进行了一项回顾性多中心、病例对照研究。纳入标准包括根据临床、实验室和放射学标准确诊为ACC的患者，以及对疑似CBD结石进行内镜超声检查（EUS）的患者。纳入112例患者，其中53例（47.3%）经EUS诊断为CBD结石。结果在单变量分析中，年龄（OR 1.038，P=0.001）、总胆红素（mg/dl）（OR 1.429，P=0.02）和我们预测的CBD宽度（mm）（OR 1.314，P=0.01）在预测CBD结石方面具有统计学意义，在多元回归分析中仍然具有显著性。我们开发了一个包含这三个参数的诊断评分，并根据系数估计为每个变量分配权重。低临界值0与CBD结石的敏感性为100%相关，而高临界值3与敏感性为10%相关，特异性为96.6%，阳性预测值为67%（ROC为0.7558）。我们用独立队列（ROC为0.7416）验证了该评分，其敏感性为46.6%，特异性为91.5%，PPV为87.1%。结论我们建议将该评分作为辅助手段，将ACC患者分为伴发CBD结石的低或高概率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号