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首页> 外文期刊>Pediatrics: Official Publication of the American Academy of Pediatrics >Vestibular, Gaze, and Balance Disorders in Asymptomatic Congenital Cytomegalovirus Infection
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Vestibular, Gaze, and Balance Disorders in Asymptomatic Congenital Cytomegalovirus Infection

机译：在无症状先天性胞嘧啶病毒感染中的前庭，凝视和平衡障碍

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BACKGROUND AND OBJECTIVES: Congenital cytomegalovirus (cCMV) is the leading nongenetic cause of sensorineural hearing loss and developmental disabilities. Because there are limited data from studies of vestibular involvement in select groups of children with cCMV, the true frequency of vestibular disorders in cCMV is likely underestimated. Our objective for this study is to determine the prevalence of vestibular, gaze, and balance disorders in a cohort of children with asymptomatic cCMV. METHODS: Comprehensive vestibular, gaze, and balance assessments were performed in 40 children with asymptomatic cCMV. The function of semicircular canals of the inner ear and vestibulo-visual tract were assessed by measuring vestibulo-ocular reflex in a computer-driven motorized rotary chair; inner ear saccular function was assessed by using cervical vestibular evoked myogenic potential; gaze stability during head movement was assessed by using clinical dynamic visual acuity, and balance was assessed by using the sensory organization test and the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition. Test results for each variable were compared with those of a control group without cCMV and/or compared to age-matched normative published data. RESULTS: Vestibular disorders were evident in 45% of the cohort on the basis of rotary chair and cervical vestibular evoked myogenic potential testing, suggesting abnormalities in semicircular canals, the utricle and saccule of the inner ear, and vestibulo-visual tracts. Additionally, 46% of the cohort had difficulties maintaining gaze during head movement, and one-third to one-half of the cohort had difficulties maintaining balance. CONCLUSIONS: Vestibular, gaze, and balance disorders are highly prevalent in children with asymptomatic cCMV. Systematic screening for vestibular disorders will be used to determine the full clinical impact for the development of effective interventions.
机译：背景和目的：先天性巨细胞病毒（cCMV）是感音神经性听力损失和发育障碍的主要非遗传原因。由于对某些cCMV儿童前庭受累的研究数据有限，因此可能低估了cCMV中前庭障碍的真实发生率。本研究的目的是确定无症状cCMV儿童队列中前庭、凝视和平衡障碍的患病率。方法：对40例无症状cCMV患儿进行全面的前庭、凝视和平衡评估。在计算机驱动的电动旋转椅上测量前庭眼反射，评估内耳半规管和前庭视路的功能；采用颈前庭诱发肌源性电位评价内耳球囊功能；头部运动时的凝视稳定性通过临床动态视力进行评估，平衡性通过感觉组织测试和Bruininks-Oseretsky运动能力测试（第二版）进行评估。将每个变量的测试结果与没有cCMV的对照组进行比较，和/或与年龄匹配的标准公布数据进行比较。结果：根据旋转椅和颈部前庭诱发肌源性电位测试，45%的队列患者出现明显的前庭障碍，提示半规管、内耳椭圆囊和球囊以及前庭视觉束异常。此外，46%的受试者在头部运动时难以保持凝视，三分之一到一半的受试者难以保持平衡。结论：前庭、凝视和平衡障碍在无症状cCMV患儿中非常普遍。前庭障碍的系统筛查将用于确定有效干预措施开发的全部临床影响。

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