Beyond energy storage: roles of glycogen metabolism in health and disease

Zhang Huafeng; Ma Jingwei; Tang Ke; Huang Bo

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Beyond energy storage: roles of glycogen metabolism in health and disease

机译：超越储能：糖原代谢在健康和疾病中的作用

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Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical roles in cell differentiation, signaling, redox regulation, and stemness under various physiological and pathophysiological conditions. Such versatile functions have been revealed by various forms of glycogen storage diseases. Here, we outline the source of carbon flux in glycogen metabolism and discuss how glycogen metabolism guides CD8(+) T-cell memory formation and maintenance. Likewise, we review how this affects macrophage polarization and inflammatory responses. Furthermore, we dissect how glycogen metabolism supports tumor development by promoting tumor-repopulating cell growth in hypoxic tumor microenvironments. This review highlights the essential role of the gluconeogenesis-glycogenesis-glycogenolysis-PPP metabolic chain in redox homeostasis, thus providing insights into potential therapeutic strategies against major chronic diseases including cancer.

机译：除了在肝脏和肌肉中储存和供应能量外，糖原还在各种生理和病理生理条件下的细胞分化、信号传导、氧化还原调节和干性中发挥关键作用。各种形式的糖原储存疾病揭示了这种多功能。在这里，我们概述了糖原代谢中碳通量的来源，并讨论了糖原代谢如何指导CD8（+）T细胞记忆的形成和维持。同样，我们回顾了这如何影响巨噬细胞极化和炎症反应。此外，我们还分析了糖原代谢如何通过促进缺氧肿瘤微环境中的肿瘤细胞生长来支持肿瘤发展。这篇综述强调了糖异生糖原分解PPP代谢链在氧化还原稳态中的重要作用，从而为包括癌症在内的主要慢性疾病的潜在治疗策略提供了见解。

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来源
《The FEBS journal》 |2021年第12期|共12页
作者
Zhang Huafeng; Ma Jingwei; Tang Ke; Huang Bo;
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作者单位

Huazhong Univ Sci &

Technol Tongji Med Coll Sch Basic Med Dept Pathol Wuhan Peoples R China;

Huazhong Univ Sci &

Technol Tongji Med Coll Dept Immunol Wuhan Peoples R China;

Huazhong Univ Sci &

Technol Tongji Med Coll Dept Biochem &

Mol Biol Wuhan Peoples R China;

Huazhong Univ Sci &

Technol Tongji Med Coll Dept Biochem &

Mol Biol Wuhan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
G6P; gluconeogenesis; glycogen metabolism; PPP; UDPG;

机译：G6P;糖异生;糖原代谢;购买力平价;UDPG;

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7. SIRT4 and Its Roles in Energy and Redox Metabolism in Health Disease and During Exercise [O] . Yumei Han, Shi Zhou, Sonja Coetzee, -1

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8. Beyond energy storage: roles of glycogen metabolism in health and disease [O] . Huafeng Zhang, Jingwei Ma, Ke Tang, 2020

机译：超越储能：糖原代谢在健康和疾病中的作用
9. Evidence for the Absence of Cerebral Glucose-6-Phosphatase Activity in Glycogen Storage Disease Type I (Von Gierke's Disease) [R] . Phelps, M. E., Mazziotta, J. C., Hawkins, R. A., 1981

机译：I型糖原贮积病（Von Gierke病）中缺乏脑葡萄糖-6-磷酸酶活性的证据

Beyond energy storage: roles of glycogen metabolism in health and disease

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