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Words of advice: teaching enzyme kinetics

机译：建议的话：教学酶动力学

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Enzymology is concerned with the study of enzyme structure, function, regulation and kinetics. It is an interdisciplinary subject that can be treated as an exclusive sphere of exhaustive inquiry within mathematical, physico-chemical and biological sciences. Hence, teaching of enzymology, in general, and enzyme kinetics, in particular, should be undertaken in an interdisciplinary manner for a holistic appreciation of this subject. Further, analogous examples from everyday life should form an integral component of the teaching for an intuitive grasp of the subject matter. Furthermore, simulation-based appreciation of enzyme kinetics should be preferred over simplifying assumptions and approximations of traditional enzyme kinetics teaching. In this Words of Advice, I outline the domain depth of enzymology across the various disciplines and provide initial ideas on how appropriate analogies can provide firm insights into the subject. Further, I demonstrate how an intuitive feel for the subject can help not only in grasping abstract concepts but also extending it in experimental design and subsequent interpretation. Use of simulations in grasping complex concepts is also advocated given the advantages this medium offers over traditional approaches involving images and molecular models. Furthermore, I discuss the merits of incorporating the historical backdrop of major discoveries in enzymological teaching. We, at AstraZeneca, have experimented with this approach with the desired outcome of generating interest in the subject from people practising diverse disciplines.
机译：酶学研究酶的结构、功能、调节和动力学。它是一门跨学科的学科，可以被视为数学、物理化学和生物科学中的一个专属领域。因此，一般来说，酶学的教学，尤其是酶动力学的教学，应该以跨学科的方式进行，以全面理解这门学科。此外，日常生活中的类似例子应该成为教学的一个组成部分，以便直观地掌握主题。此外，基于模拟的酶动力学评估应该优先于简化传统酶动力学教学的假设和近似。在这句建议的话中，我概述了各个学科的酶学领域深度，并就适当的类比如何提供对该学科的坚定见解提供了初步想法。此外，我还展示了对该主题的直观感受如何不仅有助于掌握抽象概念，还可以在实验设计和后续解释中扩展它。鉴于这种媒介与涉及图像和分子模型的传统方法相比具有优势，因此也提倡使用模拟来掌握复杂的概念。此外，我还讨论了在酶学教学中融入重大发现的历史背景的优点。我们在阿斯利康进行了这种方法的实验，取得了期望的结果，即从从事不同学科的人那里激发对该学科的兴趣。

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