ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

Ren Tingting; Chen Haotai; Liu Xinsheng; Wang Yanxue; Fan Aixia; Qi Linlin; Pan Li; Bai Wenlong; Zhang Yongguang; Sun Yuefeng

首页> 外文期刊>The FEBS journal >ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

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ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

机译：ID1通过靶向干扰素途径抑制口蹄疫病毒复制

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Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell-like properties, but its roles in virus infection are less understood. In the present study, we have clearly shown that the foot-and-mouth disease virus (FMDV) promotes ID1 degradation via Cdh1-mediated ubiquitination to facilitate its replication. Mechanistic investigations reveal Forkhead Box O1 (FOXO1) as an ID1 partner, which suppresses interferon regulatory factors 3 expression and interferon (IFN) production. Further investigation identified that ID1 suppresses FOXO1 transcription activity through HDAC4-mediated deacetylation, promoting IFN production and antiviral immune response. These studies establish a prominent role for ID1 in suppressing FDMV replication, which may be extended to other viruses.

机译：DNA结合抑制剂1（ID1）蛋白因其在肿瘤发生和维持干细胞样特性中的功能而被广泛研究，但其在病毒感染中的作用尚不清楚。在本研究中，我们清楚地表明口蹄疫病毒（FMDV）通过Cdh1介导的泛素化促进ID1降解，以促进其复制。机制研究显示，叉头盒O1（FOXO1）是ID1的一个伙伴，它抑制干扰素调节因子3的表达和干扰素（IFN）的产生。进一步研究发现，ID1通过HDAC4介导的去乙酰化抑制FOXO1转录活性，促进IFN产生和抗病毒免疫应答。这些研究证实了ID1在抑制FDMV复制中的重要作用，这种作用可能扩展到其他病毒。

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来源
《The FEBS journal》 |2021年第14期|共18页
作者
Ren Tingting; Chen Haotai; Liu Xinsheng; Wang Yanxue; Fan Aixia; Qi Linlin; Pan Li; Bai Wenlong; Zhang Yongguang; Sun Yuefeng;
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作者单位

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Univ S Florida Coll Med Dept Pathol &

Cell Biol Tampa FL USA;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

Chinese Acad Agr Sci State Key Lab Vet Etiol Biol Natl Foot &

Mouth Dis Reference Lab Key Lab Anim Virol Minist Agr Lanzhou Vet Res Ins Lanzhou 730046 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
deacetylation; footamp; 8208; andamp; 8208; mouth disease virus; ID1; interferon; ubiquitination;

机译：脱乙酰化;足部;8208;及;8208;口腔疾病病毒;ID1;干扰素;泛素化;

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1. Foot-and-Mouth Disease Virus Inhibits RIP2 Protein Expression to Promote Viral Replication [J] . Huisheng Liu, Qiao Xue, Zixiang Zhu, 中国病毒学：英文版 . 2021,第004期
2. The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus Replication [J] . Qiao Xue, Huisheng Liu, Qiaoying Zeng, 中国病毒学：英文版 . 2019,第006期
3. Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway [J] . Dan Li, Caoqi Lei, Zhisheng Xu, Scientific reports. . 2016,第1期

机译：口蹄疫病毒非结构蛋白3A抑制干扰素-β信号通路
4. Short Hairpin RNA Targeted to the Highly Conserved Regions of L and 3D Gene Inhibits Replication of Foot-and-Mouth Disease Virus in vitro [J] . Li-Jun Chen, Yin-Guang Li, Ming-Qiu Zhao, Journal of animal and veterinary advances . 2011,第21期

机译：靶向L和3D基因高度保守区域的短发夹RNA抑制口蹄疫病毒在体外的复制
5. Short hairpin RNA targeted to the highly conserved 2B nonstructural protein coding region inhibits replication of multiple serotypes of foot-and-mouth disease virus [J] . Santos TDL, Wu QH, Botton SD, Virology . 2005,第2期

机译：靶向高度保守的2B非结构蛋白编码区的短发夹RNA抑制口蹄疫病毒多种血清型的复制
6. Inhibition of Foot-and-Mouth Disease Virus Replication by the Bovine Mx1 Protein [C] . Cai Kuojun, Qiao Jun, Meng Qingling, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：牛Mx1蛋白抑制口蹄疫病毒复制
7. VARIATIONS IN THE ANTIGENIC DETERMINANTS INVOLVED IN THE NEUTRALIZATION OF FOOT-AND-MOUTH DISEASE VIRUS TYPE O INDUCED BY VARIOUS REPLICATIVE SYSTEMS. [D] . BOONCHUVIT-COGBURN, BOONBUNGEARN. 1979

机译：各种复制系统诱发的O型口蹄疫病毒中和中涉及的抗原决定因素的变化。
8. Cellular DNAJA3 a Novel VP1-Interacting Protein Inhibits Foot-and-Mouth Disease Virus Replication by Inducing Lysosomal Degradation of VP1 and Attenuating Its Antagonistic Role in the Beta Interferon Signaling Pathway [O] . Wei Zhang, Fan Yang, Zixiang Zhu, 2019

机译：细胞DNAJA3一种新型的VP1相互作用蛋白通过诱导VP1的溶酶体降解并减弱其在β干扰素信号通路中的拮抗作用抑制口蹄疫病毒复制。
9. Foot-and-mouth disease virus VP1 target the MAVS to inhibit type-I interferon signaling and VP1 E83K mutation results in virus attenuation [O] . Pathum Ekanayaka, Seo-Yong Lee, Thilina U. B. Herath, 2020

机译：口蹄疫病毒VP1靶向MAV，抑制I型干扰素信令和VP1 E83K突变导致病毒衰减
10. Commercial Simian Virus Antisera that Inhibit Virus Replication in Primary Monkey Kidney Cell Cultures [R] . Hughes, J. H. , Hamparian, V. V. 1981

机译：商业猿猴病毒抗血清抑制原代猴肾细胞培养中的病毒复制

ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

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